Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PI4KA | P42356 | 1/20 | 0.53 |
| ▸ | PI4K2B | Q8TCG2 | 1/20 | 0.53 |
| ▸ | PI4K2A | Q9BTU6 | 1/20 | 0.53 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.53 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.51 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.51 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.51 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7203458 | 1.00 | PI4KA (0.53) | PI4KAPI4K2BPI4K2API4KBADORA3 | |
| SCHEMBL7203845 | 0.86 | ADORA2A (0.53) | PI4KAPI4K2BPI4K2API4KBADORA3 | |
| SCHEMBL7203847 | 0.86 | ADORA2A (0.53) | PI4KAPI4K2BPI4K2API4KBADORA3 | |
| SCHEMBL7202938 | 0.85 | ADORA1 (0.66) | ADORA3ADORA2AADORA1ADORA2B | |
| SCHEMBL7202949 | 0.85 | ADORA1 (0.66) | ADORA3ADORA2AADORA1ADORA2B | |
| SCHEMBL25090698 | 0.83 | ADORA3 (0.60) | ADORA3ADORA2AADORA1ADORA2BTDP1 | |
| SCHEMBL19366689 | 0.83 | ADORA3 (0.60) | ADORA3ADORA2AADORA1ADORA2BTDP1 | |
| SCHEMBL18493278 | 0.83 | LMNA (0.65) | PI4KAPI4K2BPI4K2API4KBADORA3 | |
| SCHEMBL17205571 | 0.83 | LMNA (0.65) | PI4KAPI4K2BPI4K2API4KBADORA3 | |
| SCHEMBL23914964 | 0.83 | LMNA (0.65) | PI4KAPI4K2BPI4K2API4KBADORA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6610665-B1 | Treatment of inflammatory diseases, asthma or chronic obstructive pulmonary disease | SMITHKLINE BEECHAM CORPORATION | 2003-08-26 | — | — | US | disclosed |
| EP-1056759-B1 | 2-(PURIN-9-YL) -TETRAHYDROFURAN-3, 4-DIOL DERIVATIVES | GLAXO GROUP LTD (GB) | 2002-09-04 | — | — | EP | disclosed |