Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA1 | P30542 | 6/20 | 0.66 |
| ▸ | ADORA3 | P0DMS8 | 6/20 | 0.66 |
| ▸ | ADORA2A | P29274 | 5/20 | 0.66 |
| ▸ | PGK1 | P00558 | 3/20 | 0.60 |
| ▸ | PGK2 | P07205 | 3/20 | 0.60 |
| ▸ | NT5E | P21589 | 2/20 | 0.58 |
| ▸ | TSHR | P16473 | 2/20 | 0.57 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.57 |
| ▸ | THPO | P40225 | 1/20 | 0.57 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.52 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.52 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7202938 | 1.00 | ADORA1 (0.66) | ADORA1ADORA3ADORA2APGK1PGK2 | |
| SCHEMBL5055239 | 0.95 | ADORA1 (0.60) | ADORA1ADORA3ADORA2APGK1PGK2 | |
| SCHEMBL19366689 | 0.91 | ADORA3 (0.60) | ADORA1ADORA3ADORA2ANT5EADORA2B | |
| SCHEMBL25090698 | 0.91 | ADORA3 (0.60) | ADORA1ADORA3ADORA2ANT5EADORA2B | |
| SCHEMBL5062524 | 0.89 | ADORA3 (0.73) | ADORA1ADORA3ADORA2APGK1PGK2 | |
| SCHEMBL7203455 | 0.85 | PI4KA (0.53) | ADORA1ADORA3ADORA2AADORA2B | |
| SCHEMBL7203458 | 0.85 | PI4KA (0.53) | ADORA1ADORA3ADORA2AADORA2B | |
| SCHEMBL31201331 | 0.85 | ADORA1 (0.88) | ADORA1ADORA3ADORA2APGK1PGK2 | |
| SCHEMBL24601292 | 0.84 | ADORA3 (0.62) | ADORA1ADORA3ADORA2AADORA2B | |
| SCHEMBL13238338 | 0.84 | ADORA3 (0.73) | ADORA1ADORA3ADORA2ATSHRNFKB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6610665-B1 | Treatment of inflammatory diseases, asthma or chronic obstructive pulmonary disease | SMITHKLINE BEECHAM CORPORATION | 2003-08-26 | — | — | US | disclosed |
| EP-1056759-B1 | 2-(PURIN-9-YL) -TETRAHYDROFURAN-3, 4-DIOL DERIVATIVES | GLAXO GROUP LTD (GB) | 2002-09-04 | — | — | EP | disclosed |