SCHEMBL5055723

SCHEMBL5055723

Cc1ccc(N(c2ccc(C)cc2)c2ccc(C3(c4ccc(N(c5ccc(C)cc5)c5ccc(C)cc5)cc4)CCC(C(C)(C)C)CC3)cc2)cc1

nearest known ligand 0.42

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
AQP3 Q92482 1/20 0.42
ATM Q13315 3/20 0.37
ALPL P05186 1/20 0.37
ALDH1A1 P00352 4/20 0.35
TSHR P16473 1/20 0.35
GAA P10253 2/20 0.34
USP2 O75604 1/20 0.34
MAPT P10636 1/20 0.34
OPRM1 P35372 1/20 0.33
MAOB P27338 4/20 0.33
MAOA P21397 2/20 0.33
MEN1 O00255 1/20 0.31
KMT2A Q03164 1/20 0.31
AQP1 P29972 1/20 0.31
KDM4E B2RXH2 1/20 0.31
POLB P06746 1/20 0.31
HPGD P15428 1/20 0.31
SMN1; SMN2 Q16637 1/20 0.31
TDP1 Q9NUW8 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9003197 0.87 OPRM1 (0.40) ATMALPLALDH1A1GAAUSP2
SCHEMBL77382 0.83 ALDH1A1 (0.38) ALDH1A1TSHROPRM1MAOBMAOA
SCHEMBL13049480 0.82 ALDH1A1 (0.46) ALDH1A1TSHROPRM1MAOBMAOA
SCHEMBL75338 0.79 ESR1 (0.47) ALDH1A1TSHRMAPTOPRM1MEN1
SCHEMBL5055717 0.78 AQP3 (0.38) AQP3ATMALPLALDH1A1GAA
SCHEMBL5452904 0.78 ESR1 (0.48) ALDH1A1TSHRMAPTOPRM1KMT2A
SCHEMBL12306231 0.78 ESR1 (0.48) ALDH1A1TSHRMAPTOPRM1KMT2A
SCHEMBL21168792 0.78 ESR1 (0.48) ALDH1A1TSHRMAPTOPRM1KMT2A
SCHEMBL13879208 0.78 ESR1 (0.48) ALDH1A1TSHRMAPTOPRM1KMT2A
SCHEMBL39661 0.78 ESR1 (0.48) ALDH1A1TSHRMAPTOPRM1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7354685-B2 Photoconductive imaging members XEROX CORPORATION (US) 2008-04-08 US claimed
US-20060166116-A1 Hole blocking layer of a metal alkoxide (titanium tetraisopropoxide), an aminosiloxane (3-aminopropyl)triethoxysilane), and a polymer binder containing epoxy groups (Epon\"); photogenerating layer (selenium, trigonal selenium, selenium alloy), and charge transport layer (tetraphenylbiphenylenediamines) XEROX CORPORATION 2006-07-27 US claimed
US-6824940-B2 ELECTRIC FIELD WITHIN THE OVERCOAT IS INCREASED OR BOOSTED, WHICH IN TURN CAN ALLEVIATE THE PROBLEM IN APPLICATIONS THAT ARE MOBILITY LIMITED DUE TO THE LOW DIELECTRIC CONSTANT OF THE OVERCOAT LAYER XEROX CORPORATION 2004-11-30 US claimed
US-20040161682-A1 Photoconductive imaging members XEROX CORPORATION 2004-08-19 US claimed
US-4127412-A BIS(AMINOARYL)ALKANES EASTMAN KODAK COMPANY (US) 1978-11-28 US claimed
US-7354685-B2 Photoconductive imaging members XEROX CORPORATION (US) 2008-04-08 US disclosed
US-7354685-B2 Photoconductive imaging members XEROX CORPORATION (US) 2008-04-08 US disclosed
US-7354685-B2 Photoconductive imaging members XEROX CORPORATION (US) 2008-04-08 US disclosed
US-20060166116-A1 Hole blocking layer of a metal alkoxide (titanium tetraisopropoxide), an aminosiloxane (3-aminopropyl)triethoxysilane), and a polymer binder containing epoxy groups (Epon\"); photogenerating layer (selenium, trigonal selenium, selenium alloy), and charge transport layer (tetraphenylbiphenylenediamines) XEROX CORPORATION 2006-07-27 US disclosed
US-6824940-B2 ELECTRIC FIELD WITHIN THE OVERCOAT IS INCREASED OR BOOSTED, WHICH IN TURN CAN ALLEVIATE THE PROBLEM IN APPLICATIONS THAT ARE MOBILITY LIMITED DUE TO THE LOW DIELECTRIC CONSTANT OF THE OVERCOAT LAYER XEROX CORPORATION 2004-11-30 US disclosed
US-20040161682-A1 Photoconductive imaging members XEROX CORPORATION 2004-08-19 US disclosed
US-5124218-A Photoconductor element for making multiple copies and process for using same EASTMAN KODAK COMPANY (US) 1992-06-23 US disclosed
US-5053304-A Photoconductor element for making multiple copies and process for using same EASTMAN KODAK COMPANY (US) 1991-10-01 US disclosed
EP-0115198-B1 ELECTROPHOTOGRAPHIC PHOTOCONDUCTIVE ELEMENTS TOMOEGAWA PAPER MANUFACTURING COMPANY LIMITED (JP) 1987-03-11 EP disclosed
US-4539282-A SENSITIZED ZINC OXIDE, POLYCARBONATE BINDER AND AROMATIC DIAMINE TOMOEGAWA PAPER MANUFACTURING COMPANY LIMITED (JP) 1985-09-03 US disclosed
EP-0115198-A1 Electrophotographic photoconductive elements TOMOEGAWA PAPER MANUFACTURING COMPANY LIMITED (JP) 1984-08-08 EP disclosed
US-4127412-A BIS(AMINOARYL)ALKANES EASTMAN KODAK COMPANY (US) 1978-11-28 US disclosed