Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR6 | P46095 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 4/20 | 0.37 |
| ▸ | TRPC3 | Q13507 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | ACHE | P22303 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | CCR1 | P32246 | 3/20 | 0.34 |
| ▸ | DDR1 | Q08345 | 1/20 | 0.34 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.34 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.34 |
| ▸ | DDR2 | Q16832 | 1/20 | 0.34 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.34 |
| ▸ | MAP3K20 | Q9NYL2 | 1/20 | 0.34 |
| ▸ | MAP3K2 | Q9Y2U5 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.33 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.33 |
| ▸ | TRPC1 | P48995 | 1/20 | 0.33 |
| ▸ | STIM1 | Q13586 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5060789 | 0.88 | PTPN1 (0.41) | GPR6MAPTTRPC3KDM4EALDH1A1 | |
| SCHEMBL5059312 | 0.83 | KDM4E (0.39) | GPR6MAPTTRPC3KDM4EALDH1A1 | |
| SCHEMBL1086640 | 0.79 | GPR6 (0.40) | GPR6MAPTTRPC3KDM4EALDH1A1 | |
| SCHEMBL5011733 | 0.76 | EPHX2 (0.39) | KDM4EALDH1A1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL1086962 | 0.67 | GPR6 (0.41) | GPR6MAPTTRPC3CCR1PTPN1 | |
| SCHEMBL2858054 | 0.65 | GPR6 (0.53) | GPR6MAPTTRPC3KDM4EALDH1A1 | |
| SCHEMBL28696410 | 0.65 | ALDH1A1 (0.76) | GPR6MAPTTRPC3KDM4EALDH1A1 | |
| SCHEMBL2856010 | 0.64 | MAPT (0.58) | GPR6MAPTTRPC3KDM4EALDH1A1 | |
| SCHEMBL2064195 | 0.64 | MAPT (0.76) | GPR6MAPTTRPC3KDM4EALDH1A1 | |
| SCHEMBL2857536 | 0.64 | TP53 (0.59) | GPR6MAPTKDM4EALDH1A1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1910381-A2 | SUBSTITUTED 1-OXA-3,8-DIAZASPIRO[4.5]-DECAN-2-ON- COMPOUNDS AND THE USE THEREOF FOR PRODUCING DRUGS | Grünenthal GmbH (DE) | 2008-04-16 | — | — | EP | disclosed |
| WO-2007000325-A2 | SUBSTITUTED 1-OXA-3,8-DIAZASPIRO[4.5]-DECAN-2-ON- COMPOUNDS AND THE USE THEREOF FOR PRODUCING DRUGS | Grünenthal GmbH (DE) | 2007-01-04 | — | — | WO | disclosed |