Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 1/20 | 0.39 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | PRKAB2 | O43741 | 3/20 | 0.38 |
| ▸ | PRKAG1 | P54619 | 3/20 | 0.38 |
| ▸ | PRKAA2 | P54646 | 3/20 | 0.38 |
| ▸ | PRKAA1 | Q13131 | 3/20 | 0.38 |
| ▸ | PRKAG3 | Q9UGI9 | 3/20 | 0.38 |
| ▸ | PRKAG2 | Q9UGJ0 | 3/20 | 0.38 |
| ▸ | PRKAB1 | Q9Y478 | 3/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.37 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.37 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.37 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.37 |
| ▸ | EPAS1 | Q99814 | 3/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5011835 | 0.80 | CYP1A2 (0.43) | HPGDPRKAB2PRKAG1PRKAA2PRKAA1 | |
| SCHEMBL5056159 | 0.76 | GPR6 (0.38) | MEN1KMT2ASMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL1086650 | 0.74 | EPHX2 (0.47) | EPHX2MEN1HPGDTSHRKMT2A | |
| SCHEMBL5011747 | 0.71 | KCNK3 (0.40) | HPGDKMT2ACYP3A4CYP2C9ALDH1A1 | |
| SCHEMBL5011879 | 0.69 | KMT2A (0.38) | MEN1HPGDTSHRKMT2ASMN1; SMN2 | |
| SCHEMBL5013344 | 0.68 | CNR2 (0.38) | MEN1HPGDTSHRKMT2ACYP3A4 | |
| SCHEMBL5012911 | 0.68 | PPARG (0.36) | HPGDTSHRKMT2AHIF1ACYP3A4 | |
| SCHEMBL5011651 | 0.68 | CHRM2 (0.44) | MEN1TSHRKMT2AADRB2SMN1; SMN2 | |
| SCHEMBL5015147 | 0.67 | KMT2A (0.37) | EPHX2MEN1TSHRKMT2AKDM4E | |
| SCHEMBL1086092 | 0.64 | RIPK1 (0.39) | EPHX2MEN1KMT2ACHRM4SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1910381-A2 | SUBSTITUTED 1-OXA-3,8-DIAZASPIRO[4.5]-DECAN-2-ON- COMPOUNDS AND THE USE THEREOF FOR PRODUCING DRUGS | Grünenthal GmbH (DE) | 2008-04-16 | — | — | EP | disclosed |
| WO-2007000325-A2 | SUBSTITUTED 1-OXA-3,8-DIAZASPIRO[4.5]-DECAN-2-ON- COMPOUNDS AND THE USE THEREOF FOR PRODUCING DRUGS | Grünenthal GmbH (DE) | 2007-01-04 | — | — | WO | disclosed |