Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | PARP1 | P09874 | 1/20 | 0.37 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.36 |
| ▸ | SYK | P43405 | 3/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.35 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.35 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | PLAU | P00749 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | AHR | P35869 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19902793 | 0.85 | ALDH1A1 (0.38) | ALDH1A1KDM4EHPGDHSD17B10P2RX7 | |
| SCHEMBL30011332 | 0.83 | KDM4E (0.55) | ALDH1A1KDM4EHPGDHSD17B10P2RX7 | |
| SCHEMBL353231 | 0.83 | KDM4E (0.55) | ALDH1A1KDM4EHPGDHSD17B10P2RX7 | |
| SCHEMBL1460028 | 0.82 | P2RX7 (0.46) | ALDH1A1KDM4EHPGDHSD17B10P2RX7 | |
| Ammonia Solution, Strong SCHEMBL28941143 | 0.81 | KDM4E (0.54) | ALDH1A1KDM4EHPGDHSD17B10P2RX7 | |
| Fluoride SCHEMBL11495081 | 0.81 | KDM4E (0.54) | ALDH1A1KDM4EHPGDHSD17B10P2RX7 | |
| SCHEMBL17064036 | 0.81 | P2RX7 (0.38) | ALDH1A1KDM4EHPGDHSD17B10P2RX7 | |
| SCHEMBL25277611 | 0.79 | P2RX7 (0.39) | ALDH1A1KDM4EHPGDHSD17B10P2RX7 | |
| SCHEMBL9768749 | 0.78 | P2RX7 (0.44) | ALDH1A1KDM4EHPGDHSD17B10P2RX7 | |
| SCHEMBL12118515 | 0.77 | ALDH1A1 (0.38) | ALDH1A1KDM4EHPGDHSD17B10P2RX7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1874777-A1 | H-PYRIMIDO[4,5-B]INDOLE DERIVATIVES, THEIR PREPARATION AND THERAPEUTIC USE | Sanofi-Aventis (FR) | 2008-01-09 | — | — | EP | disclosed |
| WO-2006111648-A1 | H-PYRIMIDO[4,5-B]INDOLE DERIVATIVES, THEIR PREPARATION AND THERAPEUTIC USE | SANOFI-AVENTIS (FR) | 2006-10-26 | — | — | WO | disclosed |