Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.38 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | BLM | P54132 | 1/20 | 0.33 |
| ▸ | AGER | Q15109 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | PDE4A | P27815 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5056591 | 0.85 | ALDH1A1 (0.41) | ALDH1A1L3MBTL1P2RX7KDM4EHSD17B10 | |
| SCHEMBL17064036 | 0.81 | P2RX7 (0.38) | ALDH1A1L3MBTL1P2RX7KDM4EHSD17B10 | |
| SCHEMBL7256602 | 0.81 | P2RX7 (0.43) | ALDH1A1L3MBTL1P2RX7KDM4EHSD17B10 | |
| SCHEMBL12118515 | 0.81 | ALDH1A1 (0.38) | ALDH1A1L3MBTL1P2RX7KDM4EHSD17B10 | |
| SCHEMBL1460028 | 0.79 | P2RX7 (0.46) | ALDH1A1L3MBTL1P2RX7KDM4EHSD17B10 | |
| SCHEMBL9768749 | 0.78 | P2RX7 (0.44) | ALDH1A1L3MBTL1P2RX7KDM4EHSD17B10 | |
| Acetic Acid SCHEMBL16666942 | 0.78 | KDM4E (0.53) | ALDH1A1L3MBTL1P2RX7KDM4ETDP1 | |
| SCHEMBL5739085 | 0.77 | KDM4E (0.38) | ALDH1A1L3MBTL1P2RX7KDM4EHSD17B10 | |
| SCHEMBL123202 | 0.77 | KDM4E (0.57) | ALDH1A1L3MBTL1P2RX7KDM4ETDP1 | |
| SCHEMBL28459948 | 0.77 | L3MBTL1 (0.38) | ALDH1A1L3MBTL1P2RX7KDM4EHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3033337-B1 | SUBSTITUTED IMIDAZOLES AS N-TYPE CALCIUM CHANNEL BLOCKERS | JANSSEN PHARMACEUTICA NV (BE) | 2018-02-28 | — | — | EP | disclosed |