Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX15 | P16050 | 2/20 | 0.78 |
| ▸ | MAPT | P10636 | 1/20 | 0.57 |
| ▸ | GRIN2D | O15399 | 5/20 | 0.52 |
| ▸ | GRIN3B | O60391 | 5/20 | 0.52 |
| ▸ | GRIN1 | Q05586 | 5/20 | 0.52 |
| ▸ | GRIN2A | Q12879 | 5/20 | 0.52 |
| ▸ | GRIN2B | Q13224 | 5/20 | 0.52 |
| ▸ | GRIN2C | Q14957 | 5/20 | 0.52 |
| ▸ | GRIN3A | Q8TCU5 | 5/20 | 0.52 |
| ▸ | THRB | P10828 | 2/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | RECQL | P46063 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Midafotel SCHEMBL974897 | 0.87 | ALOX15 (1.00) | ALOX15MAPTGRIN2DGRIN3BGRIN1 | |
| Midafotel SCHEMBL1061150 | 0.87 | ALOX15 (1.00) | ALOX15MAPTGRIN2DGRIN3BGRIN1 | |
| Midafotel SCHEMBL1061155 | 0.87 | ALOX15 (1.00) | ALOX15MAPTGRIN2DGRIN3BGRIN1 | |
| Midafotel SCHEMBL726553 | 0.87 | ALOX15 (1.00) | ALOX15MAPTGRIN2DGRIN3BGRIN1 | |
| SCHEMBL5058496 | 0.85 | ALOX15 (0.80) | ALOX15MAPTGRIN2DGRIN3BGRIN1 | |
| SCHEMBL5058498 | 0.82 | ALOX15 (0.74) | ALOX15MAPTGRIN2DGRIN3BGRIN1 | |
| SCHEMBL8828049 | 0.80 | ALOX15 (0.71) | ALOX15MAPTGRIN2DGRIN3BGRIN1 | |
| SCHEMBL20694120 | 0.80 | ALOX15 (0.68) | ALOX15MAPTGRIN2DGRIN3BGRIN1 | |
| SCHEMBL9677431 | 0.78 | ALOX15 (0.69) | ALOX15MAPTGRIN2DGRIN3BGRIN1 | |
| SCHEMBL11501479 | 0.76 | ALOX15 (0.62) | ALOX15MAPTGRIN2DGRIN3BGRIN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080317834-A1 | Compounds and methods for modulating cerebral amyloid angiopathy | NEUROCHEM (INTERNATIONAL) LIMITED (CH) | 2008-12-25 | — | — | US | disclosed |
| US-20070078082-A1 | Methods and compositions to treat glycosaminoglycan-associated molecular interactions | NEUROCHEM (INTERNATIONAL) LIMITED (CH) | 2007-04-05 | — | — | US | disclosed |
| US-20060116347-A1 | Methods and compositions to treat glycosaminoglycan-associated molecular interactions | KIACTA SARL (CH) | 2006-06-01 | — | — | US | disclosed |
| US-6670399-B2 | Contacting a blood vessel wall cell with an A beta 40 inhibitor, such that cerebral amyloid angiopathy is inhibited | NEUROCHEM (INTERNATIONAL) LIMITED (CH) | 2003-12-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080317834-A1 | Compounds and methods for modulating cerebral amyloid angiopathy | APP, PYGB, MAPT | ALOX15 1106/4885MAPT 3/4885GRIN2D 2278/4885 |
| US-20060116347-A1 | Methods and compositions to treat glycosaminoglycan-associated molecular interactions | HPSE, CSGALNACT1, CD44 | ALOX15 1554/4885MAPT 3991/4885GRIN2D 2206/4885 |
| US-20070078082-A1 | Methods and compositions to treat glycosaminoglycan-associated molecular interactions | HPSE, CD44, CSGALNACT1 | ALOX15 2036/4885MAPT 3743/4885GRIN2D 2283/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.