Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX15 | P16050 | 2/20 | 0.71 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | GRIN2D | O15399 | 5/20 | 0.49 |
| ▸ | GRIN3B | O60391 | 5/20 | 0.49 |
| ▸ | GRIN1 | Q05586 | 5/20 | 0.49 |
| ▸ | GRIN2A | Q12879 | 5/20 | 0.49 |
| ▸ | GRIN2B | Q13224 | 5/20 | 0.49 |
| ▸ | GRIN2C | Q14957 | 5/20 | 0.49 |
| ▸ | GRIN3A | Q8TCU5 | 5/20 | 0.49 |
| ▸ | THRB | P10828 | 2/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | RECQL | P46063 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9677431 | 0.89 | ALOX15 (0.69) | ALOX15MAPTGRIN2DGRIN3BGRIN1 | |
| SCHEMBL5058498 | 0.85 | ALOX15 (0.74) | ALOX15MAPTGRIN2DGRIN3BGRIN1 | |
| Midafotel SCHEMBL726553 | 0.83 | ALOX15 (1.00) | ALOX15MAPTGRIN2DGRIN3BGRIN1 | |
| Midafotel SCHEMBL1061150 | 0.83 | ALOX15 (1.00) | ALOX15MAPTGRIN2DGRIN3BGRIN1 | |
| Midafotel SCHEMBL974897 | 0.83 | ALOX15 (1.00) | ALOX15MAPTGRIN2DGRIN3BGRIN1 | |
| Midafotel SCHEMBL1061155 | 0.83 | ALOX15 (1.00) | ALOX15MAPTGRIN2DGRIN3BGRIN1 | |
| SCHEMBL5058496 | 0.81 | ALOX15 (0.80) | ALOX15MAPTGRIN2DGRIN3BGRIN1 | |
| SCHEMBL5058501 | 0.80 | ALOX15 (0.78) | ALOX15MAPTGRIN2DGRIN3BGRIN1 | |
| SCHEMBL8828056 | 0.76 | GRIN2D (0.72) | ALOX15MAPTGRIN2DGRIN3BGRIN1 | |
| SCHEMBL20694120 | 0.74 | ALOX15 (0.68) | ALOX15MAPTGRIN2DGRIN3BGRIN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5595983-A | ANTAGONIST ACTION AT AMINO ACID RECEPTORS, ANTICONVULSANTS | BRITISH TECHNOLOGY GROUP LIMITED (GB) | 1997-01-21 | — | — | US | claimed |
| US-5399693-A | Substituted piperazine-2-carboxylic acids and derivatives thereof | BRITISH TECHNOLOGY GROUP LIMITED (GB) | 1995-03-21 | — | — | US | claimed |
| EP-0159889-B1 | 4-SUBSTITUTED PIPERAZINE-2-CARBOXYLIC ACIDS PROCESS AND PHARMACEUTICAL COMPOSITIONS | BTG INTERNATIONAL LIMITED (GB) | 1992-09-30 | — | — | EP | claimed |
| US-5399693-A | Substituted piperazine-2-carboxylic acids and derivatives thereof | BRITISH TECHNOLOGY GROUP LIMITED (GB) | 1995-03-21 | — | — | US | disclosed |