Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 1/20 | 0.62 |
| ▸ | PIM1 | P11309 | 4/20 | 0.56 |
| ▸ | AKR1B1 | P15121 | 4/20 | 0.56 |
| ▸ | PIM2 | Q9P1W9 | 3/20 | 0.56 |
| ▸ | NPC1 | O15118 | 1/20 | 0.56 |
| ▸ | RAB9A | P51151 | 1/20 | 0.56 |
| ▸ | HPGD | P15428 | 2/20 | 0.51 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.49 |
| ▸ | ADAMTS5 | Q9UNA0 | 2/20 | 0.48 |
| ▸ | GSK3B | P49841 | 3/20 | 0.48 |
| ▸ | ESRRA | P11474 | 2/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.47 |
| ▸ | CDC7 | O00311 | 1/20 | 0.47 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.47 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.47 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.47 |
| ▸ | PHKG2 | P15735 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3793560 | 1.00 | PPARG (0.62) | PPARGPIM1AKR1B1PIM2NPC1 | |
| SCHEMBL13347261 | 1.00 | PPARG (0.62) | PPARGPIM1AKR1B1PIM2NPC1 | |
| SCHEMBL3802111 | 1.00 | PPARG (0.62) | PPARGPIM1AKR1B1PIM2NPC1 | |
| SCHEMBL3793562 | 1.00 | PPARG (0.62) | PPARGPIM1AKR1B1PIM2NPC1 | |
| SCHEMBL13347260 | 1.00 | PPARG (0.62) | PPARGPIM1AKR1B1PIM2NPC1 | |
| SCHEMBL12631330 | 0.91 | AKR1B1 (0.56) | PPARGPIM1AKR1B1PIM2NPC1 | |
| SCHEMBL28525448 | 0.91 | AKR1B1 (0.57) | PPARGPIM1AKR1B1PIM2NPC1 | |
| SCHEMBL29018404 | 0.91 | AKR1B1 (0.57) | PPARGPIM1AKR1B1PIM2NPC1 | |
| SCHEMBL6036475 | 0.91 | AKR1B1 (0.57) | PPARGPIM1AKR1B1PIM2NPC1 | |
| SCHEMBL6036473 | 0.91 | AKR1B1 (0.57) | PPARGPIM1AKR1B1PIM2NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7407978-B2 | Heterocyclic analogs of diphenylethylene compounds | THERACOS, INC. (US) | 2008-08-05 | — | — | US | disclosed |
| US-20060235062-A1 | Novel heterocyclic analogs of diphenylethylene compounds | THERACOS, INC. (US) | 2006-10-19 | — | — | US | disclosed |
| US-20030181494-A1 | Novel heterocyclic analogs of diphenylethylene compounds | SEED, BRIAN | 2003-09-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030181494-A1 | Novel heterocyclic analogs of diphenylethylene compounds | FFAR2, FFAR4, GPR119 | PPARG 10/4885PIM1 1299/4885AKR1B1 1453/4885 |
| US-20060235062-A1 | Novel heterocyclic analogs of diphenylethylene compounds | FFAR2, FFAR4, GPR119 | PPARG 10/4885PIM1 1299/4885AKR1B1 1453/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.