Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.59 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.54 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.54 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.54 |
| ▸ | KCNMA1 | Q12791 | 1/20 | 0.52 |
| ▸ | HPGD | P15428 | 1/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | PHGDH | O43175 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 3/20 | 0.50 |
| ▸ | GAA | P10253 | 2/20 | 0.50 |
| ▸ | NPC1 | O15118 | 3/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.49 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.49 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.49 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30413407 | 1.00 | MEN1 (0.59) | MEN1KMT2ANPSR1CYP2C9CYP2C19 | |
| SCHEMBL505915 | 1.00 | MEN1 (0.59) | MEN1KMT2ANPSR1CYP2C9CYP2C19 | |
| SCHEMBL29505642 | 0.81 | KMT2A (0.63) | MEN1KMT2ANPSR1CYP2C9CYP2C19 | |
| SCHEMBL195876 | 0.81 | KMT2A (0.63) | MEN1KMT2ANPSR1CYP2C9CYP2C19 | |
| SCHEMBL9363929 | 0.78 | ALDH1A1 (0.74) | MEN1KMT2ANPSR1CYP2C9CYP2C19 | |
| SCHEMBL11754251 | 0.78 | KMT2A (0.59) | MEN1KMT2ANPSR1CYP2C9CYP2C19 | |
| SCHEMBL6857920 | 0.78 | KMT2A (0.73) | MEN1KMT2ANPSR1CYP2C9CYP2C19 | |
| SCHEMBL11332310 | 0.78 | KMT2A (0.73) | MEN1KMT2ANPSR1CYP2C9CYP2C19 | |
| SCHEMBL13058017 | 0.77 | ALDH1A1 (0.49) | MEN1KMT2ANPSR1CYP2C9CYP2C19 | |
| SCHEMBL29689204 | 0.77 | HPGD (0.45) | MEN1KMT2ANPSR1CYP2C9CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116102455-A | Preparation method of 2- (hydroxyimino) -N- (2-nitrophenyl) acetamide | 南通泰禾化工股份有限公司 | 2023-05-12 | — | — | CN | claimed |
| CN-116102455-A | Preparation method of 2- (hydroxyimino) -N- (2-nitrophenyl) acetamide | 南通泰禾化工股份有限公司 | 2023-05-12 | — | — | CN | disclosed |
| CN-116102455-A | Preparation method of 2- (hydroxyimino) -N- (2-nitrophenyl) acetamide | 南通泰禾化工股份有限公司 | 2023-05-12 | — | — | CN | disclosed |
| CN-116102455-A | Preparation method of 2- (hydroxyimino) -N- (2-nitrophenyl) acetamide | 南通泰禾化工股份有限公司 | 2023-05-12 | — | — | CN | disclosed |
| EP-2414328-B1 | DIHYDROOROTATE DEHYDROGENASE INHIBITORS | MERCK SERONO SA (CH) | 2021-05-26 | — | — | EP | disclosed |
| CN-104030987-B | DIHYDROOROTATE DEHYDROGENASE INHIBITORS | 默克雪兰诺有限公司 | 2017-04-12 | — | — | CN | disclosed |
| US-9006454-B2 | Dihydroorotate dehydrogenase inhibitors | MERCK SERONO S.A. (CH) | 2015-04-14 | — | — | US | disclosed |
| CN-104030987-A | DIHYDROOROTATE DEHYDROGENASE INHIBITORS | MERCK SERONO SA | 2014-09-10 | — | — | CN | disclosed |
| EP-2414328-A2 | DIHYDROOROTATE DEHYDROGENASE INHIBITORS | Merck Serono S.A. (CH) | 2012-02-08 | — | — | EP | disclosed |
| US-20120028959-A1 | DIHYDROOROTATE DEHYDROGENASE INHIBITORS | MERCK SERONO S.A. (CH) | 2012-02-02 | — | — | US | disclosed |
| WO-2010115736-A2 | DIHYDROOROTATE DEHYDROGENASE INHIBITORS | MERCK SERONO S.A. (CH) | 2010-10-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120028959-A1 | DIHYDROOROTATE DEHYDROGENASE INHIBITORS | DHODH, FH, DPYD | MEN1 1133/4885KMT2A 836/4885NPSR1 3850/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.