Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | KMO | O15229 | 1/20 | 0.45 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | NR4A2 | P43354 | 3/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | ABCC9 | O60706 | 1/20 | 0.43 |
| ▸ | ABCC8 | Q09428 | 1/20 | 0.43 |
| ▸ | KCNJ11 | Q14654 | 1/20 | 0.43 |
| ▸ | KCNJ8 | Q15842 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.42 |
| ▸ | RELA | Q04206 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5068065 | 0.85 | SMN1; SMN2 (0.50) | SMN1; SMN2KMOLRRK2CYP2C19ALDH1A1 | |
| SCHEMBL5063444 | 0.85 | SMN1; SMN2 (0.50) | SMN1; SMN2KMOLRRK2CYP2C19ALDH1A1 | |
| SCHEMBL29037233 | 0.84 | MKNK1 (0.50) | SMN1; SMN2KMOLRRK2CYP2C19ALDH1A1 | |
| SCHEMBL2884923 | 0.78 | PDK2 (0.57) | SMN1; SMN2CYP2C19ALDH1A1CYP2C9KMT2A | |
| SCHEMBL5068078 | 0.76 | TP53 (0.43) | SMN1; SMN2LRRK2CYP2C19ALDH1A1KMT2A | |
| SCHEMBL31254922 | 0.74 | PDK2 (0.45) | SMN1; SMN2CYP2C19ALDH1A1NR4A2CYP2C9 | |
| SCHEMBL23226657 | 0.74 | PDK2 (0.51) | SMN1; SMN2CYP2C19ALDH1A1NR4A2CYP2C9 | |
| SCHEMBL17185620 | 0.73 | PDK2 (0.48) | SMN1; SMN2ALDH1A1NR4A2MAPTNPC1 | |
| SCHEMBL5184506 | 0.73 | ALDH1A1 (0.54) | SMN1; SMN2CYP2C19ALDH1A1CYP2C9MAPT | |
| SCHEMBL6617411 | 0.73 | JMJD6 (0.49) | SMN1; SMN2CYP2C19NR4A2CYP2C9KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080161294-A1 | Urea derivative, medicinal composition containing the same, and medicinal use of these | KISSEI PHARMACEUTICAL CO., LTD. (JP) | 2008-07-03 | — | — | US | disclosed |
| EP-1867639-A1 | UREA DERIVATIVE, MEDICINAL COMPOSITION CONTAINING THE SAME, AND MEDICINAL USE OF THESE | Kissei Pharmaceutical Co., Ltd. (JP) | 2007-12-19 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080161294-A1 | Urea derivative, medicinal composition containing the same, and medicinal use of these | AVPR2, UTS2R, GPR119 | SMN1; SMN2 3056/4885KMO 3087/4885LRRK2 1614/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.