SCHEMBL5067153

SCHEMBL5067153

COc1cc(N)c(Br)cc1C(=O)OC(=O)c1ccc(N)c(F)c1

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HDAC1 Q13547 1/20 0.43
HDAC6 Q9UBN7 1/20 0.43
ACHE P22303 3/20 0.41
CYP1A2 P05177 2/20 0.41
CYP2D6 P10635 2/20 0.41
HTR1A P08908 1/20 0.41
ADRA2A P08913 1/20 0.41
DRD1 P21728 1/20 0.41
PTGS1 P23219 1/20 0.41
DRD3 P35462 1/20 0.41
GAA P10253 2/20 0.40
LMNA P02545 2/20 0.40
HTT P42858 2/20 0.40
MAPK1 P28482 1/20 0.40
RAB9A P51151 1/20 0.40
ALDH1A1 P00352 5/20 0.38
KDM4E B2RXH2 2/20 0.38
L3MBTL1 Q9Y468 1/20 0.38
HPGD P15428 3/20 0.37
MAPT P10636 2/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5067150 0.85 HTT (0.55) HDAC1HDAC6ACHECYP1A2CYP2D6
SCHEMBL169553 0.75 GAA (0.66) ACHECYP1A2CYP2D6HTR1AADRA2A
Hydrochloric Acid SCHEMBL7410965 0.74 GAA (0.64) ACHECYP1A2CYP2D6HTR1AADRA2A
SCHEMBL866041 0.72 LCK (0.59) ACHECYP1A2CYP2D6HTR1AADRA2A
SCHEMBL1457756 0.72 KDM4E (0.61) HDAC1HDAC6CYP1A2GAALMNA
Hydrochloric Acid SCHEMBL4418745 0.71 MAPT (0.59) HDAC1HDAC6CYP1A2GAALMNA
SCHEMBL3343357 0.71 ACHE (0.53) ACHECYP1A2CYP2D6HTR1AADRA2A
SCHEMBL28362778 0.71 ACHE (0.48) ACHECYP1A2CYP2D6HTR1AADRA2A
SCHEMBL6109360 0.70 GAA (0.66) ACHECYP1A2CYP2D6GAAHTT
SCHEMBL2596409 0.68 ALDH1A1 (0.54) ACHEGAALMNAHTTMAPK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1966119-A1 PHOTOCROSSLINKABLE MATERIALS Rolic AG (CH) 2008-09-10 EP disclosed
WO-2007071091-A1 PHOTOCROSSLINKABLE MATERIALS ROLIC AG (CH) 2007-06-28 WO disclosed