Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | ANPEP | P15144 | 2/20 | 0.35 |
| ▸ | ENPEP | Q07075 | 2/20 | 0.35 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | CNR2 | P34972 | 2/20 | 0.30 |
| ▸ | LTA4H | P09960 | 1/20 | 0.30 |
| ▸ | LNPEP | Q9UIQ6 | 1/20 | 0.30 |
| ▸ | CNR1 | P21554 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3392036 | 0.75 | ALDH1A1 (0.38) | TDP1 | |
| SCHEMBL6938015 | 0.74 | TDP1 (0.35) | TDP1ANPEPENPEPALOX5LTA4H | |
| SCHEMBL8895135 | 0.74 | TDP1 (0.35) | TDP1ANPEPENPEPALOX5LTA4H | |
| SCHEMBL7349947 | 0.74 | TDP1 (0.35) | TDP1ANPEPENPEPALOX5LTA4H | |
| SCHEMBL17592140 | 0.74 | ANPEP (0.37) | ANPEPENPEPMAPT | |
| SCHEMBL17592776 | 0.74 | ANPEP (0.37) | ANPEPENPEPMAPT | |
| SCHEMBL17592139 | 0.74 | ANPEP (0.37) | ANPEPENPEPMAPT | |
| SCHEMBL17069436 | 0.73 | — | — | |
| SCHEMBL12540125 | 0.73 | — | — | |
| SCHEMBL7103418 | 0.72 | ALDH1A1 (0.41) | TDP1ALOX5LTA4H |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1933622-A2 | BICYCLOHETEROARYL COMPOUNDS AS P2X7 MODULATORS AND USES THEREOF | Renovis, Inc. (US) | 2008-06-25 | — | — | EP | disclosed |
| WO-2007109192-A2 | BICYCLOHETEROARYL COMPOUNDS AS P2X7 MODULATORS AND USES THEREOF | RENOVIS, INC. (US) | 2007-09-27 | — | — | WO | disclosed |