Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN2 | P17706 | 1/20 | 0.58 |
| ▸ | PTPRB | P23467 | 1/20 | 0.58 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.58 |
| ▸ | ABCC1 | P33527 | 2/20 | 0.55 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.50 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.47 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.45 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.45 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5063495 | 0.84 | KMT2A (0.64) | MAPK10KDM4ESMN1; SMN2NPC1RAB9A | |
| SCHEMBL14218016 | 0.80 | PTPN1 (0.50) | PTPN1LMNAHPGDKDM4ESMN1; SMN2 | |
| SCHEMBL5065942 | 0.80 | MAPK10 (0.53) | MAPK10LMNAHPGDKDM4EMAPK8 | |
| SCHEMBL10741969 | 0.78 | PTPN2 (0.64) | PTPN2PTPRBPTPN6ABCC1HCAR2 | |
| SCHEMBL1704195 | 0.78 | PTK2 (0.71) | PTPN2PTPRBPTPN6ABCC1HCAR2 | |
| SCHEMBL10741093 | 0.77 | PTPN2 (0.58) | PTPN2PTPRBPTPN6ABCC1HCAR2 | |
| SCHEMBL13764835 | 0.77 | PTPN2 (0.72) | PTPN2PTPRBPTPN6ABCC1HCAR2 | |
| SCHEMBL10741084 | 0.77 | PTPN2 (0.62) | PTPN2PTPRBPTPN6ABCC1HCAR2 | |
| SCHEMBL4959777 | 0.76 | ABCC1 (0.57) | PTPN2PTPRBPTPN6ABCC1HCAR2 | |
| SCHEMBL25381542 | 0.76 | PTPN2 (0.56) | PTPN2PTPRBPTPN6ABCC1HCAR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080102068-A1 | Mitotic Kinesin Inhibitors | MERCK SHARP & DOHME CORP. | 2008-05-01 | — | — | US | disclosed |
| US-20080102068-A1 | Mitotic Kinesin Inhibitors | MERCK SHARP & DOHME CORP. | 2008-05-01 | — | — | US | disclosed |
| EP-1856128-A2 | MITOTIC KINESIN INHIBITORS | Merck & Co., Inc. (US) | 2007-11-21 | — | — | EP | disclosed |
| WO-2006078574-A2 | MITOTIC KINESIN INHIBITORS | MERCK & CO., INC. (US) | 2006-07-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080102068-A1 | Mitotic Kinesin Inhibitors | KIF5B, KIF2C, KIF18B | PTPN2 3809/4885PTPRB 2107/4885PTPN6 3645/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.