Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.45 |
| ▸ | HPGD | P15428 | 3/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.45 |
| ▸ | GAA | P10253 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | TLR4 | O00206 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | PDE4A | P27815 | 1/20 | 0.37 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.37 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.37 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9782199 | 0.81 | MAPT (0.47) | MAPTKDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL14809551 | 0.76 | MAPT (0.43) | MAPTKDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL27405623 | 0.71 | MAPT (0.45) | MAPTKDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL6346612 | 0.71 | MAPT (0.45) | MAPTKDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL907623 | 0.71 | MAPT (0.45) | MAPTKDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL1322979 | 0.71 | RAB9A (0.49) | MAPTKDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL158378 | 0.71 | MAPT (0.42) | MAPTKDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL9671321 | 0.71 | MAPT (0.42) | MAPTKDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL4065281 | 0.71 | MAPT (0.42) | MAPTKDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL9672478 | 0.71 | MAPT (0.42) | MAPTKDM4EALDH1A1HPGDHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009089057-A1 | AMIDE DERIVATIVES AS ION-CHANNEL LIGANDS AND PHARMACEUTICAL COMPOSITIONS AND METHODS OF USING THE SAME | RENOVIS, INS. (US) | 2009-07-16 | — | — | WO | disclosed |
| EP-1531811-B1 | DERIVATIVES OF 3-HYDROXY-4-(CYCLYL-ALKYLAMINOALKYL)-5-PHENYL-1H-PYRAZOLE AS ANTAGONISTS OF THE GONADOTROPIN RELEASING HORMONE (GNRH) FOR USE IN THE TREATMENT OF SEX HORMONE RELATED CONDITIONS, SUCH AS PROSTATIC OF UTERINE CANCER | ASTRAZENECA AB (SE) | 2008-10-29 | — | — | EP | disclosed |