Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 2/20 | 0.38 |
| ▸ | MELK | Q14680 | 1/20 | 0.38 |
| ▸ | GALR3 | O60755 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | SCN8A | Q9UQD0 | 7/20 | 0.37 |
| ▸ | SCN1A | P35498 | 6/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | MLNR | O43193 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.36 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.36 |
| ▸ | SSTR5 | P35346 | 1/20 | 0.35 |
| ▸ | CCR3 | P51677 | 1/20 | 0.35 |
| ▸ | CCR5 | P51681 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5069728 | 1.00 | LTA4H (0.38) | LTA4HMELKGALR3RAB9ASCN8A | |
| SCHEMBL19349010 | 0.92 | MAP4K4 (0.41) | LTA4HMELKGALR3RAB9ASCN8A | |
| SCHEMBL4006418 | 0.82 | CCR3 (0.41) | LTA4HMELKGALR3RAB9AALDH1A1 | |
| SCHEMBL403110 | 0.82 | CCR3 (0.41) | LTA4HMELKGALR3RAB9AALDH1A1 | |
| SCHEMBL403108 | 0.82 | CCR3 (0.41) | LTA4HMELKGALR3RAB9AALDH1A1 | |
| SCHEMBL4006400 | 0.78 | LTA4H (0.36) | LTA4HTP53 | |
| SCHEMBL400753 | 0.78 | ADRB2 (0.41) | GALR3RAB9ACCR3 | |
| SCHEMBL400551 | 0.78 | ADRB2 (0.41) | GALR3RAB9ACCR3 | |
| SCHEMBL4003553 | 0.78 | ADRB2 (0.41) | GALR3RAB9ACCR3 | |
| SCHEMBL398834 | 0.77 | KCNH2 (0.43) | GALR3RAB9AALDH1A1KCNH2GPR119 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1959960-A2 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS AND METHODS | Cytokinetics, Inc. (US) | 2008-08-27 | — | — | EP | disclosed |
| WO-2007070683-A2 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS AND METHODS | CYTOKINETICS, INC. (US) | 2007-06-21 | — | — | WO | disclosed |