Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.60 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.55 |
| ▸ | MEN1 | O00255 | 3/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.55 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.55 |
| ▸ | HPGD | P15428 | 1/20 | 0.55 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.55 |
| ▸ | CYTH2 | Q99418 | 1/20 | 0.53 |
| ▸ | CA2 | P00918 | 2/20 | 0.52 |
| ▸ | CA12 | O43570 | 1/20 | 0.52 |
| ▸ | CA9 | Q16790 | 1/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | CA1 | P00915 | 1/20 | 0.50 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.47 |
| ▸ | P4HB | P07237 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4128140 | 0.84 | KMT2A (0.48) | BCL2L1MCL1KMT2AMEN1ALDH1A1 | |
| SCHEMBL23093409 | 0.78 | ALDH1A1 (0.62) | KMT2AMEN1ALDH1A1KDM4ECYP3A4 | |
| SCHEMBL29390524 | 0.78 | ALDH1A1 (0.65) | BCL2L1MCL1KMT2AMEN1ALDH1A1 | |
| SCHEMBL610080 | 0.78 | ALDH1A1 (0.65) | BCL2L1MCL1KMT2AMEN1ALDH1A1 | |
| SCHEMBL18392406 | 0.75 | MCL1 (1.00) | BCL2L1MCL1 | |
| SCHEMBL4122558 | 0.75 | MEN1 (0.62) | BCL2L1MCL1KMT2AMEN1ALDH1A1 | |
| SCHEMBL29539746 | 0.75 | MCL1 (1.00) | BCL2L1MCL1 | |
| SCHEMBL5330654 | 0.75 | CA2 (0.69) | KMT2AMEN1ALDH1A1KDM4ECYP3A4 | |
| SCHEMBL7498033 | 0.74 | CA2 (0.83) | KMT2AMEN1ALDH1A1KDM4ECYP3A4 | |
| SCHEMBL6577363 | 0.73 | CA2 (0.71) | MCL1KMT2AMEN1ALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1890993-A2 | BENZOIC ACID DERIVATIVES THAT ARE MODULATORS OR ANTAGONISTS OF GLYR | AstraZeneca AB (SE) | 2008-02-27 | — | — | EP | claimed |
| WO-2006121390-A2 | BENZOIC ACID DERIVATIVES THAT ARE MODULATORS OR AGONISTS OF GLYR | ASTRAZENECA AB (SE) | 2006-11-16 | — | — | WO | claimed |