SCHEMBL5069831

SCHEMBL5069831

CC1CN(c2c(CO[Si](c3ccccc3)(c3ccccc3)C(C)(C)C)cc(CC=O)c(F)c2F)CC(C)O1

nearest known ligand 0.34

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 3/20 0.31
SMYD2 Q9NRG4 2/20 0.31
MEN1 O00255 1/20 0.31
KMT2A Q03164 1/20 0.31
PKM P14618 1/20 0.30
KDM4E B2RXH2 1/20 0.30
GAA P10253 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2307647 1.00 ALDH1A1 (0.31) ALDH1A1SMYD2MEN1KMT2APKM
SCHEMBL2305796 0.88 ALDH1A1 (0.33) ALDH1A1SMYD2MEN1KMT2APKM
SCHEMBL3068264 0.88 ALDH1A1 (0.35) ALDH1A1SMYD2MEN1KMT2AKDM4E
SCHEMBL2310214 0.88
SCHEMBL5015624 0.86 ALDH1A1 (0.32) ALDH1A1MEN1KMT2AKDM4EGAA
SCHEMBL3056971 0.86 ALDH1A1 (0.33) ALDH1A1SMYD2MEN1KMT2APKM
SCHEMBL2305811 0.86 SCN9A (0.32) ALDH1A1SMYD2MEN1KMT2AKDM4E
SCHEMBL5053849 0.85 RORC (0.33) ALDH1A1MEN1KMT2AKDM4EGAA
SCHEMBL5014338 0.84 KDM4E (0.36) ALDH1A1SMYD2MEN1KMT2AKDM4E
SCHEMBL3062273 0.84 KDM4E (0.36) ALDH1A1SMYD2MEN1KMT2AKDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1888597-A2 ANTIBACTERIAL AGENTS Warner-Lambert Company LLC (US) 2008-02-20 EP disclosed
WO-2006120563-A2 ANTIBACTERIAL AGENTS WARNER-LAMBERT COMPANY LLC (US) 2006-11-16 WO disclosed