Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 4/20 | 0.41 |
| ▸ | GFER | P55789 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 4/20 | 0.40 |
| ▸ | HTT | P42858 | 4/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 5/20 | 0.40 |
| ▸ | HPGD | P15428 | 4/20 | 0.40 |
| ▸ | MEN1 | O00255 | 4/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | RORC | P51449 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5068725 | 1.00 | TSHR (0.42) | TSHRGAAGFERLMNAHTT | |
| SCHEMBL5068732 | 1.00 | TSHR (0.42) | TSHRGAAGFERLMNAHTT | |
| SCHEMBL5068723 | 0.85 | GAA (0.46) | GAAGFERLMNAHTTALOX15 | |
| SCHEMBL14319936 | 0.84 | TSHR (0.39) | TSHRGAAGFERLMNAHTT | |
| SCHEMBL22310449 | 0.82 | GAA (0.43) | GAAGFERLMNAHTTALOX15 | |
| SCHEMBL5066619 | 0.82 | PTGS2 (0.38) | TSHRGAAGFERLMNAHTT | |
| SCHEMBL5066614 | 0.82 | PTGS2 (0.38) | TSHRGAAGFERLMNAHTT | |
| SCHEMBL5068717 | 0.82 | PTGS2 (0.38) | TSHRGAAGFERLMNAHTT | |
| SCHEMBL5068271 | 0.81 | NPC1 (0.47) | TSHRGAALMNAMAPTMEN1 | |
| SCHEMBL5068274 | 0.81 | NPC1 (0.47) | TSHRGAALMNAMAPTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1653947-B1 | (4-HYDROXYPHENYL)-1H-INDOLE-3-CARBALDEHYDE OXIME DERIVATIVES AS ESTROGENIC AGENTS | WYETH CORP (US) | 2008-01-16 | — | — | EP | claimed |