Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 1/20 | 0.38 |
| ▸ | USP14 | P54578 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 3/20 | 0.36 |
| ▸ | GAA | P10253 | 3/20 | 0.36 |
| ▸ | HTT | P42858 | 3/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | MAPT | P10636 | 4/20 | 0.36 |
| ▸ | MEN1 | O00255 | 3/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
| ▸ | GFER | P55789 | 1/20 | 0.35 |
| ▸ | GCGR | P47871 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | POLB | P06746 | 2/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5068717 | 1.00 | PTGS2 (0.38) | PTGS2USP14TSHRLMNAGAA | |
| SCHEMBL5066614 | 1.00 | PTGS2 (0.38) | PTGS2USP14TSHRLMNAGAA | |
| SCHEMBL5068704 | 0.88 | ALDH1A1 (0.47) | USP14LMNAHTTALDH1A1MEN1 | |
| SCHEMBL22310450 | 0.85 | USP14 (0.39) | USP14TSHRLMNAGAAHTT | |
| SCHEMBL14319938 | 0.84 | HPGD (0.36) | PTGS2USP14TSHRLMNAGAA | |
| SCHEMBL5070842 | 0.82 | TSHR (0.42) | TSHRLMNAGAAHTTALOX15 | |
| SCHEMBL5068725 | 0.82 | TSHR (0.42) | TSHRLMNAGAAHTTALOX15 | |
| SCHEMBL5068732 | 0.82 | TSHR (0.42) | TSHRLMNAGAAHTTALOX15 | |
| SCHEMBL5066622 | 0.80 | RAB9A (0.42) | LMNAGAAALDH1A1MAPTMEN1 | |
| SCHEMBL5066623 | 0.80 | RAB9A (0.42) | LMNAGAAALDH1A1MAPTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1653947-B1 | (4-HYDROXYPHENYL)-1H-INDOLE-3-CARBALDEHYDE OXIME DERIVATIVES AS ESTROGENIC AGENTS | WYETH CORP (US) | 2008-01-16 | — | — | EP | claimed |
| JP-2007502277-A | — | — | 2007-02-08 | — | — | JP | claimed |
| CN-1867329-A | (4-hydroxyphenyl)-1H-indole-3-carbaldehyde oxime derivative as estrogenic agents | WYETH CORP (US) | 2006-11-22 | — | — | CN | claimed |
| EP-1653947-A1 | (4-HYDROXYPHENYL)-1H-INDOLE-3-CARBALDEHYDE OXIME DERIVATIVES AS ESTROGENIC AGENTS | Wyeth Holdings Corporation (US) | 2006-05-10 | — | — | EP | claimed |
| US-20050059723-A1 | (Hydroxyphenyl)-1H-indole-3-carbaldehyde oxime derivatives as estrogenic agents | WYETH (US) | 2005-03-17 | — | — | US | claimed |
| WO-2005018636-A1 | (4-HYDROXYPHENYL)-1H-INDOLE-3-CARBALDEHYDE OXIME DERIVATIVE AS ESTROGENIC AGENTS | WYETH (US) | 2005-03-03 | — | — | WO | claimed |
| EP-1653947-B1 | (4-HYDROXYPHENYL)-1H-INDOLE-3-CARBALDEHYDE OXIME DERIVATIVES AS ESTROGENIC AGENTS | WYETH CORP (US) | 2008-01-16 | — | — | EP | disclosed |
| US-20070249703-A1 | (Hydroxyphenyl)-1H-Indole-3-Carbaldehyde Oxime Derivatives As Estrogenic Agents | WYETH (US) | 2007-10-25 | — | — | US | disclosed |
| US-7250440-B2 | (Hydroxyphenyl)-1H-indole-3-carbaldehyde oxime derivatives as estrogenic agents | WYETH (US) | 2007-07-31 | — | — | US | disclosed |
| CN-1867329-A | (4-hydroxyphenyl)-1H-indole-3-carbaldehyde oxime derivative as estrogenic agents | WYETH CORP (US) | 2006-11-22 | — | — | CN | disclosed |
| EP-1653947-A1 | (4-HYDROXYPHENYL)-1H-INDOLE-3-CARBALDEHYDE OXIME DERIVATIVES AS ESTROGENIC AGENTS | Wyeth Holdings Corporation (US) | 2006-05-10 | — | — | EP | disclosed |
| US-20050059723-A1 | (Hydroxyphenyl)-1H-indole-3-carbaldehyde oxime derivatives as estrogenic agents | WYETH (US) | 2005-03-17 | — | — | US | disclosed |
| WO-2005018636-A1 | (4-HYDROXYPHENYL)-1H-INDOLE-3-CARBALDEHYDE OXIME DERIVATIVE AS ESTROGENIC AGENTS | WYETH (US) | 2005-03-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070249703-A1 | (Hydroxyphenyl)-1H-Indole-3-Carbaldehyde Oxime Derivatives As Estrogenic Agents | ESR1, ESR2, GPER1 | PTGS2 533/4885USP14 2320/4885TSHR 103/4885 |
| US-20050059723-A1 | (Hydroxyphenyl)-1H-indole-3-carbaldehyde oxime derivatives as estrogenic agents | ESR1, ESR2, GPER1 | PTGS2 533/4885USP14 2320/4885TSHR 103/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.