Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCHE | P06276 | 9/20 | 0.49 |
| ▸ | PPARG | P37231 | 2/20 | 0.42 |
| ▸ | PPARA | Q07869 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.38 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.37 |
| ▸ | LTB4R2 | Q9NPC1 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL648541 | 0.93 | BCHE (0.42) | BCHEPPARGPPARATSHRHSD11B1 | |
| SCHEMBL5135239 | 0.93 | BCHE (0.47) | BCHEPPARGPPARA | |
| SCHEMBL5137333 | 0.92 | BCHE (0.44) | BCHEPPARGPPARATSHRHSD11B1 | |
| SCHEMBL5135920 | 0.91 | BCHE (0.44) | BCHEPPARGPPARATSHRHSD11B1 | |
| SCHEMBL5137926 | 0.89 | TSHR (0.41) | BCHEPPARGPPARATSHRHSD11B1 | |
| SCHEMBL5075074 | 0.88 | TSHR (0.46) | BCHETSHRHSD11B1 | |
| SCHEMBL5135358 | 0.86 | HSD11B1 (0.42) | BCHETSHRHSD11B1 | |
| SCHEMBL5072355 | 0.85 | HSD11B1 (0.45) | BCHETSHRHSD11B1 | |
| SCHEMBL5135801 | 0.85 | PPARG (0.45) | BCHEPPARGPPARATSHR | |
| SCHEMBL5134787 | 0.85 | BCHE (0.42) | BCHETSHRHSD11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1490044-A4 | COMBINATION THERAPY FOR THE TREATMENT OF CONDITIONS WITH PATHOGENIC INFLAMMATORY COMPONENTS | NEUROGEN CORP (US) | 2008-04-16 | — | — | EP | disclosed |
| EP-1490044-A1 | COMBINATION THERAPY FOR THE TREATMENT OF CONDITIONS WITH PATHOGENIC INFLAMMATORY COMPONENTS | NEUROGEN CORPORATION (US) | 2004-12-29 | — | — | EP | disclosed |
| WO-2003084524-A1 | COMBINATION THERAPY FOR THE TREATMENT OF CONDITIONS WITH PATHOGENIC INFLAMMATORY COMPONENTS | NEUROGEN CORPORATION (US) | 2003-10-16 | — | — | WO | disclosed |