Known targets — ChEMBL curated mechanism
PPARDPTGS1PTGS2dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Lysine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | POLB | P06746 | 2/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | HPGD | P15428 | 2/20 | 0.50 |
| ▸ | RECQL | P46063 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.50 |
| ▸ | PKM | P14618 | 1/20 | 0.50 |
| ▸ | APEX1 | P27695 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | TERT | O14746 | 7/20 | 0.49 |
| ▸ | TTR | P02766 | 6/20 | 0.49 |
| ▸ | LCK | P06239 | 1/20 | 0.45 |
| ▸ | BCL2 | P10415 | 1/20 | 0.44 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.44 |
| ▸ | GSR | P00390 | 1/20 | 0.43 |
| ▸ | CSNK2A2 | P19784 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Lysine SCHEMBL5073498 | 1.00 | MEN1 (0.50) | MEN1ALDH1A1POLBCYP3A4MAPT | |
| Emodic Acid SCHEMBL5075520 | 0.90 | MEN1 (0.64) | MEN1ALDH1A1POLBCYP3A4MAPT | |
| Emodic Acid SCHEMBL5081812 | 0.90 | MEN1 (0.64) | MEN1ALDH1A1POLBCYP3A4MAPT | |
| SCHEMBL5073499 | 0.85 | TERT (0.47) | MEN1ALDH1A1POLBCYP3A4MAPT | |
| Arginine SCHEMBL5073433 | 0.84 | MEN1 (0.45) | MEN1ALDH1A1POLBCYP3A4MAPT | |
| SCHEMBL5073500 | 0.82 | TERT (0.47) | MEN1ALDH1A1POLBCYP3A4MAPT | |
| SCHEMBL5073503 | 0.82 | MEN1 (0.71) | MEN1ALDH1A1POLBCYP3A4MAPT | |
| Rhein SCHEMBL5073473 | 0.81 | MEN1 (0.66) | MEN1ALDH1A1POLBCYP3A4MAPT | |
| SCHEMBL5075522 | 0.78 | MEN1 (0.53) | MEN1ALDH1A1POLBCYP3A4MAPT | |
| SCHEMBL5075521 | 0.74 | ALDH1A1 (0.50) | MEN1ALDH1A1POLBCYP3A4MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1913940-B1 | RHEIN CONJUGATES, PREPARATION METHOD THEREOF AND THEIR USES IN PRODUCING MEDICINES FOR TREATING DIABETIC NEPHROSIS, INTESTINAL ADHESION AND OSTEOARTHRITIS | CONG XIAODONG (CN) | 2018-11-21 | — | — | EP | disclosed |
| US-9181172-B2 | Rhein conjugates, preparation method thereof and their uses in producing medicines for treating diabetic nephrosis, intestinal adhesion and osteoarthritis | CONG XIAODONG (CN) | 2015-11-10 | — | — | US | disclosed |
| US-20080207758-A1 | Reaction product of rhein with bases or amino acids; antidiabetic agents; gastrointestinal disorders; antiarthritic agents | CONG XIAODONG | 2008-08-28 | — | — | US | disclosed |
| EP-1913940-A1 | RHEIN CONJUGATES, PREPARATION METHOD THEREOF AND THEIR USES IN PRODUCING MEDICINES FOR TREATING DIABETIC NEPHROSIS, INTESTINAL ADHESION AND OSTEOARTHRITIS | Jiangsu Lianchuang Pharmaceutical Technology Co. (CN) | 2008-04-23 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080207758-A1 | Reaction product of rhein with bases or amino acids; antidiabetic agents; gastrointestinal disorders; antiarthritic agents | ARGLU1, RO60, CROCC | MEN1 837/4885ALDH1A1 3432/4885POLB 1431/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.