⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7479352 | 1.00 | — | — | |
| SCHEMBL9130929 | 0.79 | TDP1 (0.37) | — | |
| SCHEMBL13822372 | 0.79 | TDP1 (0.37) | — | |
| SCHEMBL13001895 | 0.72 | — | — | |
| SCHEMBL12976171 | 0.72 | — | — | |
| SCHEMBL367022 | 0.71 | — | — | |
| SCHEMBL2257240 | 0.71 | — | — | |
| SCHEMBL367023 | 0.71 | — | — | |
| SCHEMBL6765480 | 0.71 | MMP9 (0.35) | — | |
| SCHEMBL10618639 | 0.70 | GRIN1 (0.31) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 28 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2000501738-A | — | — | 2000-02-15 | — | — | JP | claimed |
| US-5756775-A | Process to make α,α-difluoro-β-hydroxyl thiol esters | ELI LILLY AND COMPANY (US) | 1998-05-26 | — | — | US | claimed |
| WO-1997021719-A1 | α, α-DIFLUORO-β-HYDROXY THIOL ESTERS AND THEIR SYNTHESIS | ELI LILLY AND COMPANY (US) | 1997-06-19 | — | — | WO | claimed |
| EP-0779275-A2 | Alpha, Alpha - Difluoro-beta -hydroxy thiol esters and their synthesis | ELI LILLY AND COMPANY (US) | 1997-06-18 | — | — | EP | claimed |
| US-20080119421-A1 | Process for treating a biological organism | TECHNOLOGY INNOVATIONS, LLC | 2008-05-22 | — | — | US | disclosed |
| CN-1222519-C | Reverse hydroxamate inhibitors of matrix metalloproteinases | ABBOTT LAB (US) | 2005-10-12 | — | — | CN | disclosed |
| US-20050215764-A1 | Biological polymer with differently charged portions | TECHNOLOGY INNOVATIONS, LLC | 2005-09-29 | — | — | US | disclosed |
| US-6835734-B2 | (S)-3-(4-Phenyl-1-piperazinyl)-1,2-propanediol cyclic acetals, useful as intermediates for the preparation of levodropropizine | Dompé S.p.A. (IT) | 2004-12-28 | — | — | US | disclosed |
| EP-1307441-B1 | 1,3-DIOXOLANES WITH ANTITUSSIVE ACTIVITY | DOMPE SPA (IT) | 2004-05-06 | — | — | EP | disclosed |
| US-20040038989-A1 | 1,3-dioxolanes with antitussive activity | DOMPÉ FARMACEUTICI S.P.A. (IT) | 2004-02-26 | — | — | US | disclosed |
| EP-1147101-B1 | REVERSE HYDROXAMATE INHIBITORS OF MATRIX METALLOPROTEINASES | ABBOTT LAB (US) | 2002-11-20 | — | — | EP | disclosed |
| EP-1258486-A2 | Process for preparing 2,2-difluoroketene silyl o,s-acetals and alpha,alpha-difluoro-beta-silyloxy-1,3-dioxolane-4-propanoic acid o,s-esters | ELI LILLY AND COMPANY (US) | 2002-11-20 | — | — | EP | disclosed |
| US-6001994-A | Process for making gemcitabine hydrochloride | ELI LILLY AND COMPANY (US) | 1999-12-14 | — | — | US | disclosed |
| US-5912366-A | CHEMICAL INTERMEDIATES FOR GEMCITABINE AN ANTITUMOR AGENT | ELI LILLY AND COMPANY (US) | 1999-06-15 | — | — | US | disclosed |
| US-5756775-A | Process to make α,α-difluoro-β-hydroxyl thiol esters | ELI LILLY AND COMPANY (US) | 1998-05-26 | — | — | US | disclosed |
| EP-0779275-A2 | Alpha, Alpha - Difluoro-beta -hydroxy thiol esters and their synthesis | ELI LILLY AND COMPANY (US) | 1997-06-18 | — | — | EP | disclosed |
| US-5618951-A | REACTING A CHLORODIFLUOROACETATE WITH A HALOSILANE USING AN UREA SILVENT AND A REDUCING AGENT | ELI LILLY AND COMPANY (US) | 1997-04-08 | — | — | US | disclosed |
| EP-0677527-A1 | Process for preparing 2,2-difluoroketene silyl O,S-acetals and alpha, alpha-difluoro-beta-silyloxy-1,3-dioxolane-4-propanoic acid O,S-esters | ELI LILLY AND COMPANY (US) | 1995-10-18 | — | — | EP | disclosed |
| US-5428176-A | Contacting a difluorothioacetate with a halosilane in presence of reducing agent | ELI LILLY AND COMPANY (US) | 1995-06-27 | — | — | US | disclosed |
| EP-0655454-A1 | Process for preparing 2,2-difluoroketene silyl acetals and a,a-difluoro-b-silyloxy-1,3-dioxolane-4-propanoic acid esters | ELI LILLY AND COMPANY (US) | 1995-05-31 | — | — | EP | disclosed |