⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5073759 | 1.00 | — | — | |
| SCHEMBL9130929 | 0.79 | TDP1 (0.37) | — | |
| SCHEMBL13822372 | 0.79 | TDP1 (0.37) | — | |
| SCHEMBL13001895 | 0.72 | — | — | |
| SCHEMBL12976171 | 0.72 | — | — | |
| SCHEMBL367022 | 0.71 | — | — | |
| SCHEMBL2257240 | 0.71 | — | — | |
| SCHEMBL367023 | 0.71 | — | — | |
| SCHEMBL6765480 | 0.71 | MMP9 (0.35) | — | |
| SCHEMBL10618639 | 0.70 | GRIN1 (0.31) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220340893-A1 | BI-FUNCTIONAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES | NUEVOLUTION A/S (DK) | 2022-10-27 | — | — | US | disclosed |
| CN-1222519-C | Reverse hydroxamate inhibitors of matrix metalloproteinases | ABBOTT LAB (US) | 2005-10-12 | — | — | CN | disclosed |
| EP-1147101-B1 | REVERSE HYDROXAMATE INHIBITORS OF MATRIX METALLOPROTEINASES | ABBOTT LAB (US) | 2002-11-20 | — | — | EP | disclosed |
| EP-1258486-A2 | Process for preparing 2,2-difluoroketene silyl o,s-acetals and alpha,alpha-difluoro-beta-silyloxy-1,3-dioxolane-4-propanoic acid o,s-esters | ELI LILLY AND COMPANY (US) | 2002-11-20 | — | — | EP | disclosed |
| CN-1339032-A | Reverse hydroxamate inhibitors of matrix metalloproteinases | ABBOTT LAB (US) | 2002-03-06 | — | — | CN | disclosed |
| US-20020007060-A1 | Reverse hydroxamate inhibitors of matrix metalloproteinases | DAVIDSEN STEVEN K (US) | 2002-01-17 | — | — | US | disclosed |
| EP-0677527-B1 | Process for preparing 2,2-difluoroketene silyl O,S-acetals and alpha, alpha-difluoro-beta-silyloxy-1,3-dioxolane-4-propanoic acid O,S-esters | LILLY CO ELI (US) | 2002-01-16 | — | — | EP | disclosed |
| EP-1147101-A1 | REVERSE HYDROXAMATE INHIBITORS OF MATRIX METALLOPROTEINASES | ABBOTT LABORATORIES (US) | 2001-10-24 | — | — | EP | disclosed |
| US-6294573-B1 | FOR THERAPY RHEUMATOID ARTHRITIS, OSTEOARTHRITIS, OSTEOPENIAS SUCH AS OSTEOPOROSIS, PERIODONTITIS, GINGIVITIS, CORNEAL, EPIDERMAL OR GASTRIC ULCERATION, AND TUMOR GROWTH AND METASTASIS OR INVASION | ABBOTT LABORATORIES | 2001-09-25 | — | — | US | disclosed |
| EP-0655454-B1 | Process for preparing 2,2-difluoroketene silyl acetals and alpha,alpha-difluoro-beta-silyloxy-1,3-dioxolane-4-propanoic acid esters | LILLY CO ELI (US) | 2001-08-16 | — | — | EP | disclosed |
| WO-2000044739-A1 | REVERSE HYDROXAMATE INHIBITORS OF MATRIX METALLOPROTEINASES | ABBOTT LABORATORIES (US) | 2000-08-03 | — | — | WO | disclosed |
| EP-0970962-A2 | Process for preparing 2,2-difluoroketene silyl, 0, S-acetals and alpha,alpha-difluoro-beta-silyloxy-1,3-dioxolane-4-propanoic acid 0,S-esters | ELI LILLY AND COMPANY (US) | 2000-01-12 | — | — | EP | disclosed |
| US-5618951-A | REACTING A CHLORODIFLUOROACETATE WITH A HALOSILANE USING AN UREA SILVENT AND A REDUCING AGENT | ELI LILLY AND COMPANY (US) | 1997-04-08 | — | — | US | disclosed |
| EP-0677527-A1 | Process for preparing 2,2-difluoroketene silyl O,S-acetals and alpha, alpha-difluoro-beta-silyloxy-1,3-dioxolane-4-propanoic acid O,S-esters | ELI LILLY AND COMPANY (US) | 1995-10-18 | — | — | EP | disclosed |
| US-5428176-A | Contacting a difluorothioacetate with a halosilane in presence of reducing agent | ELI LILLY AND COMPANY (US) | 1995-06-27 | — | — | US | disclosed |
| EP-0655454-A1 | Process for preparing 2,2-difluoroketene silyl acetals and a,a-difluoro-b-silyloxy-1,3-dioxolane-4-propanoic acid esters | ELI LILLY AND COMPANY (US) | 1995-05-31 | — | — | EP | disclosed |