Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | NCF1 | P14598 | 1/20 | 0.38 |
| ▸ | MC4R | P32245 | 1/20 | 0.36 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.36 |
| ▸ | HTR3B | O95264 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.36 |
| ▸ | HTR3A | P46098 | 1/20 | 0.36 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.36 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.36 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.36 |
| ▸ | PRKCA | P17252 | 1/20 | 0.36 |
| ▸ | GSK3B | P49841 | 1/20 | 0.36 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6492610 | 0.86 | KMT2A (0.37) | MEN1KMT2AUSP2GAANCF1 | |
| SCHEMBL6223172 | 0.83 | MC4R (0.37) | MEN1KMT2AUSP2GAANCF1 | |
| SCHEMBL7875636 | 0.83 | NOTUM (0.39) | MEN1KMT2AUSP2GAANCF1 | |
| SCHEMBL1460335 | 0.81 | SMN1; SMN2 (0.37) | MEN1KMT2AUSP2GAANCF1 | |
| SCHEMBL1461471 | 0.80 | NPY1R (0.40) | MEN1KMT2AUSP2GAANCF1 | |
| SCHEMBL6492616 | 0.80 | MC4R (0.37) | MEN1KMT2AUSP2GAANCF1 | |
| SCHEMBL1462417 | 0.79 | OPRK1 (0.41) | MEN1KMT2AGAANCF1CYP1A2 | |
| SCHEMBL6220925 | 0.79 | MC4R (0.41) | MEN1KMT2AUSP2GAANCF1 | |
| SCHEMBL7972608 | 0.78 | NOTUM (0.43) | MEN1KMT2ASLC18A3HTR1ADRD2 | |
| Ammonia Solution, Strong SCHEMBL7888875 | 0.78 | KEAP1 (0.47) | MEN1KMT2AGAANCF1KEAP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1874318-A2 | N-ALKYL-AZACYCLOALKYL NMDA/NR2B ANTAGONISTS | Merck & Co., Inc. (US) | 2008-01-09 | — | — | EP | disclosed |
| WO-2006113471-A2 | N-ALKYL-AZACYCLOALKYL NMDA/NR2B ANTAGONISTS | MERCK & CO., INC. (US) | 2006-10-26 | — | — | WO | disclosed |