Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | PIM2 | Q9P1W9 | 2/20 | 0.38 |
| ▸ | PIM1 | P11309 | 2/20 | 0.38 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.38 |
| ▸ | NCF1 | P14598 | 1/20 | 0.37 |
| ▸ | MC4R | P32245 | 1/20 | 0.36 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.36 |
| ▸ | HTR3B | O95264 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.36 |
| ▸ | HTR3A | P46098 | 1/20 | 0.36 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.36 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.36 |
| ▸ | PRKCA | P17252 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5073795 | 0.76 | MEN1 (0.42) | MEN1KMT2AUSP2GAAPIM2 | |
| SCHEMBL13937420 | 0.75 | RPS6KB1 (0.41) | MEN1KMT2APIM2PIM1PIM3 | |
| SCHEMBL6494430 | 0.74 | MEN1 (0.42) | MEN1KMT2AUSP2GAAPIM2 | |
| SCHEMBL4668643 | 0.73 | L3MBTL3 (0.41) | MEN1KMT2AUSP2HTR3EHTR3B | |
| SCHEMBL5540633 | 0.73 | MEN1 (0.49) | MEN1KMT2AUSP2GAAPIM2 | |
| SCHEMBL6492610 | 0.73 | KMT2A (0.37) | MEN1KMT2AUSP2GAAPIM2 | |
| SCHEMBL11506767 | 0.72 | GAA (0.72) | MEN1KMT2AUSP2GAAPIM2 | |
| SCHEMBL1648457 | 0.72 | MEN1 (0.36) | MEN1KMT2AUSP2GAAPIM2 | |
| SCHEMBL6493841 | 0.72 | F10 (0.46) | MEN1KMT2AUSP2GAANCF1 | |
| SCHEMBL6221717 | 0.72 | F10 (0.48) | MEN1KMT2AUSP2GAAPIM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1874318-A2 | N-ALKYL-AZACYCLOALKYL NMDA/NR2B ANTAGONISTS | Merck & Co., Inc. (US) | 2008-01-09 | — | — | EP | disclosed |
| WO-2006113471-A2 | N-ALKYL-AZACYCLOALKYL NMDA/NR2B ANTAGONISTS | MERCK & CO., INC. (US) | 2006-10-26 | — | — | WO | disclosed |