Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.59 |
| ▸ | NPC1 | O15118 | 3/20 | 0.59 |
| ▸ | RAB9A | P51151 | 3/20 | 0.59 |
| ▸ | GAA | P10253 | 3/20 | 0.59 |
| ▸ | TP53 | P04637 | 1/20 | 0.59 |
| ▸ | POLB | P06746 | 1/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.57 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.54 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.54 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.54 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 5/20 | 0.53 |
| ▸ | NAMPT | P43490 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 9/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 9/20 | 0.52 |
| ▸ | CASP3 | P42574 | 1/20 | 0.52 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.52 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.52 |
| ▸ | CA12 | O43570 | 1/20 | 0.51 |
| ▸ | CA9 | Q16790 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27728396 | 0.80 | MEN1 (0.51) | SMN1; SMN2NPC1RAB9ATP53ALDH1A1 | |
| SCHEMBL11139322 | 0.76 | SMN1; SMN2 (0.71) | SMN1; SMN2NPC1RAB9AGAATP53 | |
| SCHEMBL1019967 | 0.76 | SMN1; SMN2 (0.78) | SMN1; SMN2NPC1RAB9AGAAALDH1A1 | |
| SCHEMBL9422337 | 0.75 | SMN1; SMN2 (0.73) | SMN1; SMN2NPC1RAB9AGAATP53 | |
| SCHEMBL20379674 | 0.75 | SMN1; SMN2 (0.64) | SMN1; SMN2NPC1RAB9AGAATP53 | |
| SCHEMBL4724997 | 0.74 | SMN1; SMN2 (1.00) | SMN1; SMN2NPC1RAB9AGAATP53 | |
| SCHEMBL1542395 | 0.74 | PDK1 (0.74) | SMN1; SMN2NPC1RAB9AGAATP53 | |
| SCHEMBL28188463 | 0.74 | ALDH1A1 (0.49) | SMN1; SMN2POLBALDH1A1MAPTMEN1 | |
| SCHEMBL21784421 | 0.74 | KMT2A (0.61) | SMN1; SMN2NPC1RAB9AGAAALDH1A1 | |
| SCHEMBL6250057 | 0.73 | HSD17B10 (0.43) | SMN1; SMN2NPC1RAB9APOLBALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1158985-A4 | OMEGA-CARBOXY ARYL SUBSTITUTED DIPHENYL UREAS AS p38 KINASE INHIBITORS | BAYER PHARMACEUTICALS CORP (US) | 2008-03-12 | — | — | EP | disclosed |
| EP-1158985-A1 | OMEGA-CARBOXY ARYL SUBSTITUTED DIPHENYL UREAS AS p38 KINASE INHIBITORS | Bayer Corporation (US) | 2001-12-05 | — | — | EP | disclosed |
| WO-2000041698-A1 | φ-CARBOXY ARYL SUBSTITUTED DIPHENYL UREAS AS p38 KINASE INHIBITORS | BAYER CORPORATION (US) | 2000-07-20 | — | — | WO | disclosed |