Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 14/20 | 0.52 |
| ▸ | RIPK1 | Q13546 | 5/20 | 0.44 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.42 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14312789 | 0.85 | CSNK2A2 (0.52) | PIK3CDRIPK1CSNK2A2CSNK2A1 | |
| SCHEMBL14888138 | 0.83 | PIK3CD (0.58) | PIK3CD | |
| SCHEMBL14327060 | 0.82 | PIK3CD (0.58) | PIK3CD | |
| SCHEMBL19690039 | 0.81 | PIK3CD (0.61) | PIK3CDRIPK1CSNK2A2CSNK2A1 | |
| SCHEMBL5141007 | 0.77 | RIPK1 (0.46) | PIK3CDRIPK1 | |
| SCHEMBL14314295 | 0.74 | PIK3CD (0.66) | PIK3CDRIPK1CSNK2A2CSNK2A1 | |
| SCHEMBL16011408 | 0.74 | ACVRL1 (0.48) | PIK3CDRIPK1CSNK2A2CSNK2A1 | |
| SCHEMBL14312974 | 0.73 | PIK3CD (0.44) | PIK3CD | |
| SCHEMBL19279724 | 0.69 | PIK3CD (0.70) | PIK3CD | |
| SCHEMBL16396984 | 0.69 | AOC3 (0.60) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1945222-A2 | PYRROLO[2,1-F] [1,2,4] TRIAZIN-4-YLAMINES IGF-1R KINASE INHIBITORS FOR THE TREATMENT OF CANCER AND OTHER HYPERPROLIFERATIVE DISEASES | Bayer HealthCare AG (DE) | 2008-07-23 | — | — | EP | disclosed |
| WO-2007056170-A2 | PYRROLO[2,1-F] [1,2,4] TRIAZIN-4-YLAMINES IGF-1R KINASE INHIBITORS FOR THE TREATMENT OF CANCER AND OTHER HYPERPROLIFERATIVE DISEASES | BAYER HEALTHCARE AG (DE) | 2007-05-18 | — | — | WO | disclosed |