Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MKNK1 | Q9BUB5 | 8/20 | 0.66 |
| ▸ | MKNK2 | Q9HBH9 | 7/20 | 0.66 |
| ▸ | MAP4K4 | O95819 | 5/20 | 0.56 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.53 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | CHEK2 | O96017 | 2/20 | 0.49 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.49 |
| ▸ | KCNQ3 | O43525 | 1/20 | 0.49 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.49 |
| ▸ | FYN | P06241 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29524193 | 0.84 | NAPRT (0.67) | NAPRTTDP1KCNQ3KCNQ2 | |
| SCHEMBL388168 | 0.84 | NAPRT (0.67) | NAPRTTDP1KCNQ3KCNQ2 | |
| SCHEMBL1109095 | 0.83 | NAPRT (0.71) | MKNK1MKNK2MAP4K4PIK3CDNAPRT | |
| Hydrochloric Acid SCHEMBL3346497 | 0.82 | NAPRT (0.64) | NAPRTTDP1KCNQ3KCNQ2 | |
| Hydrochloric Acid SCHEMBL5013500 | 0.82 | NAPRT (0.64) | NAPRTTDP1KCNQ3KCNQ2 | |
| SCHEMBL1742846 | 0.81 | NAPRT (0.53) | MKNK1MKNK2PIK3CDNAPRTKCNQ3 | |
| SCHEMBL27417480 | 0.79 | NAPRT (0.50) | MKNK1MKNK2PIK3CDNAPRTKCNQ3 | |
| SCHEMBL24198706 | 0.77 | NAPRT (0.49) | MKNK1MKNK2MAP4K4PIK3CDNAPRT | |
| SCHEMBL22575128 | 0.77 | CSNK2A1 (0.52) | PIK3CDNAPRTTDP1CHEK2KCNQ3 | |
| SCHEMBL2952147 | 0.77 | KDM4E (0.50) | MKNK1MKNK2NAPRTTDP1KCNQ3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8071768-B2 | Alkylquinoline and alkylquinazoline kinase modulators | JANSSEN PHARMACEUTICA, N.V. (BE) | 2011-12-06 | — | — | US | disclosed |
| CN-101242845-A | Synergistic modulation of FLT3 kinase using a farnesyl transferase inhibitor | JANSSEN PHARMACEUTICA NV (BE) | 2008-08-13 | — | — | CN | disclosed |
| EP-1893214-A1 | SYNERGISTIC MODULATION OF FLT3 KINASE USING ALKYLQUINOLINES AND ALKYLQUINAZOLINES | JANSSEN PHARMACEUTICA N.V. (BE) | 2008-03-05 | — | — | EP | disclosed |
| US-20070004660-A1 | Synergistic Modulation of Flt3 Kinase Using Alkylquinolines and Alkylquinazolines | JANSSEN PHARMACEUTICA, N.V. (BE) | 2007-01-04 | — | — | US | disclosed |
| WO-2006135629-A1 | SYNERGISTIC MODULATION OF FLT3 KINASE USING ALKYLQUINOLINES AND ALKYLQUINAZOLINES | JANSSEN PHARMACEUTICA N.V. (BE) | 2006-12-21 | — | — | WO | disclosed |
| US-20060281772-A1 | ALKYLQUINOLINE AND ALKYLQUINAZOLINE KINASE MODULATORS | JANSSEN PHARMACEUTICA, N.V. (BE) | 2006-12-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060281772-A1 | ALKYLQUINOLINE AND ALKYLQUINAZOLINE KINASE MODULATORS | FLT3, KIT, NTRK2 | MKNK1 847/4885MKNK2 708/4885MAP4K4 285/4885 |
| US-20070004660-A1 | Synergistic Modulation of Flt3 Kinase Using Alkylquinolines and Alkylquinazolines | FLT3, MCL1, CDC42BPG | MKNK1 689/4885MKNK2 620/4885MAP4K4 570/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.