Known targets — ChEMBL curated mechanism
ADRB1CDK4CDK6CHRM2CHRM3DPP4DRD2DRD3DRD4EGFRHRH1HTR1BHTR1DHTR1FHTR2AHTR2CHTR4SLC6A2SLC6A4
The experimentally established mechanism targets of Succinic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP2 | O75604 | 1/20 | 0.47 |
| ▸ | SLCO1B1 | Q9Y6L6 | 1/20 | 0.47 |
| ▸ | PDE4A | P27815 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 3/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | ALKBH5 | Q6P6C2 | 1/20 | 0.35 |
| ▸ | SUCNR1 | Q9BXA5 | 1/20 | 0.35 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | CTH | P32929 | 1/20 | 0.33 |
| ▸ | CBS | P35520 | 1/20 | 0.33 |
| ▸ | THPO | P40225 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | THRB | P10828 | 1/20 | 0.32 |
| ▸ | GABRR1 | P24046 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1129672 | 0.85 | LMNA (0.58) | USP2SLCO1B1PDE4ALMNAL3MBTL1 | |
| SCHEMBL1671960 | 0.85 | LMNA (0.58) | USP2SLCO1B1PDE4ALMNAL3MBTL1 | |
| SCHEMBL5032170 | 0.85 | LMNA (0.58) | USP2SLCO1B1PDE4ALMNAL3MBTL1 | |
| Mannitol SCHEMBL4971188 | 0.85 | LMNA (0.58) | USP2SLCO1B1PDE4ALMNAL3MBTL1 | |
| SCHEMBL8075862 | 0.83 | TDP1 (0.60) | USP2SLCO1B1PDE4ALMNAL3MBTL1 | |
| SCHEMBL6542053 | 0.83 | TDP1 (0.60) | USP2SLCO1B1PDE4ALMNAL3MBTL1 | |
| SCHEMBL11423256 | 0.83 | TDP1 (0.60) | USP2SLCO1B1PDE4ALMNAL3MBTL1 | |
| Sorbitol SCHEMBL34461855 | 0.83 | LMNA (0.61) | USP2SLCO1B1PDE4ALMNAL3MBTL1 | |
| Sorbitol SCHEMBL29621591 | 0.83 | LMNA (0.61) | USP2SLCO1B1PDE4ALMNAL3MBTL1 | |
| Mannitol SCHEMBL19927163 | 0.83 | LMNA (0.61) | USP2SLCO1B1PDE4ALMNAL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 24 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0598204-A1 | Wettable polymeric fabrics with durable surfactant treatment | KIMBERLY-CLARK CORPORATION (US) | 1994-05-25 | — | — | EP | claimed |
| EP-1002153-B1 | METHOD AND COMPOSITION FOR TREATING SUBSTRATES FOR WETTABILITY | KIMBERLY CLARK CO (US) | 2008-04-16 | — | — | EP | disclosed |
| EP-1187588-B1 | ABSORBENT ARTICLE COMPRISING TOPSHEET WITH LOW SURFACTANT OR NO SYNTHETIC SURFACTANT | PARAGON TRADE BRANDS INC (US) | 2006-08-02 | — | — | EP | disclosed |
| EP-0815310-B1 | WETTABLE ARTICLE | KIMBERLY CLARK CO (US) | 2003-08-27 | — | — | EP | disclosed |
| EP-0669420-B1 | Mixed surfactant system as a durable fabric coating | KIMBERLY CLARK CO (US) | 2003-03-26 | — | — | EP | disclosed |
| EP-1187588-A4 | ABSORBENT ARTICLE COMPRISING TOPSHEET WITH LOW SURFACTANT OR NO SYNTHETIC SURFACTANT | PARAGON TRADE BRANDS INC (US) | 2003-01-22 | — | — | EP | disclosed |
| US-6403858-B1 | FORMING ARTICLE BY MELT EXTRUSION FROM POLYMERIC COMPOSITION COMPRISING HYDROPHOBIC POLYMER AND SURFACE-ACTIVE AGENT ADAPTED TO MIGRATE TO SURFACE OF ARTICLE, COATING SURFACE OF ARTICLE WITH SURFACE FREE ENERGY MODIFIER | KIMBERLY-CLARK WORLDWIDE, INC. | 2002-06-11 | — | — | US | disclosed |
| EP-1187588-A1 | ABSORBENT ARTICLE COMPRISING TOPSHEET WITH LOW SURFACTANT OR NO SYNTHETIC SURFACTANT | Paragon Trade Brands, Inc. (US) | 2002-03-20 | — | — | EP | disclosed |
| EP-0736118-B1 | COATED POLYMERIC FABRIC HAVING DURABLE WETTABILITY AND REDUCED ADSORPTION OF PROTEIN | KIMBERLY CLARK CO (US) | 2001-11-14 | — | — | EP | disclosed |
| WO-2000066058-A1 | ABSORBENT ARTICLE COMPRISING TOPSHEET WITH LOW SURFACTANT OR NO SYNTHETIC SURFACTANT | PARAGON TRADE BRANDS, INC. (US) | 2000-11-09 | — | — | WO | disclosed |
| US-5618614-A | WATERPROOFING PROTECTIVE COATINGS AT INTERSTICES COMPRISING A MODIFIED POLYSILOXANE OR POLYETHERSILOXANE COPOLYMER | KIMBERLY-CLARK CORPORATION (US) | 1997-04-08 | — | — | US | disclosed |
| EP-0736118-A1 | COATED POLYMERIC FABRIC HAVING DURABLE WETTABILITY AND REDUCED ADSORPTION OF PROTEIN | KIMBERLY-CLARK CORPORATION (US) | 1996-10-09 | — | — | EP | disclosed |
| WO-1996028602-A1 | WETTABLE ARTICLE | KIMBERLY-CLARK WORLDWIDE, INC. (US) | 1996-09-19 | — | — | WO | disclosed |
| US-5540984-A | POLYETHERSILOXANE SURFACTANT; DISPOSABLE PRODUCTS | KIMBERLY-CLARK CORPORATION (US) | 1996-07-30 | — | — | US | disclosed |
| US-5525415-A | USED AS DIAPERS, FEMININE CARE PRODUCTS, INCONTINENT CARE PRODUCTS, TRAINING PANTS AND WIPES | KIMBERLY CLARK CORPORATION (US) | 1996-06-11 | — | — | US | disclosed |
| US-5500254-A | APPLYING POLYETHERSILOXANE COPOLYMER SURFACTANT | KIMBERLY-CLARK CORPORATION (US) | 1996-03-19 | — | — | US | disclosed |
| EP-0669420-A2 | Mixed surfactant system as a durable fabric coating | KIMBERLY-CLARK CORPORATION (US) | 1995-08-30 | — | — | EP | disclosed |
| WO-1995017545-A2 | COATED POLYMERIC FABRIC HAVING DURABLE WETTABILITY AND REDUCED ADSORPTION OF PROTEIN | KIMBERLY-CLARK CORPORATION (US) | 1995-06-29 | — | — | WO | disclosed |
| EP-0598204-A1 | Wettable polymeric fabrics with durable surfactant treatment | KIMBERLY-CLARK CORPORATION (US) | 1994-05-25 | — | — | EP | disclosed |
| EP-0594983-A1 | Method of applying a coating at high bath concentration and low wet pick-up to materials such as nonwovens using a brush spray applicator | KIMBERLY-CLARK CORPORATION (US) | 1994-05-04 | — | — | EP | disclosed |