Known targets — ChEMBL curated mechanism
ADORA1ADORA2AADORA2BADORA3PDE3APDE3BPDE4APDE4BPDE4CPDE4D
The experimentally established mechanism targets of Glycine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRA | P10827 | 9/20 | 0.38 |
| ▸ | THRB | P10828 | 9/20 | 0.38 |
| ▸ | PFKFB2 | O60825 | 1/20 | 0.33 |
| ▸ | PFKFB1 | P16118 | 1/20 | 0.33 |
| ▸ | PFKFB3 | Q16875 | 1/20 | 0.33 |
| ▸ | DPP4 | P27487 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3145862 | 0.97 | THRA (0.40) | THRATHRB | |
| SCHEMBL5076587 | 0.90 | THRA (0.36) | THRATHRBPFKFB2PFKFB1PFKFB3 | |
| SCHEMBL5072169 | 0.88 | THRA (0.34) | THRATHRB | |
| SCHEMBL3127279 | 0.86 | THRA (0.41) | THRATHRB | |
| SCHEMBL3137145 | 0.84 | THRB (0.41) | THRATHRB | |
| SCHEMBL5072172 | 0.82 | THRA (0.33) | THRATHRB | |
| SCHEMBL5072164 | 0.81 | THRB (0.39) | THRATHRB | |
| SCHEMBL3141231 | 0.79 | THRA (0.38) | THRATHRB | |
| SCHEMBL3137713 | 0.74 | THRA (0.36) | THRATHRB | |
| SCHEMBL3137690 | 0.74 | THRA (0.38) | THRATHRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1899309-A1 | HETEROCYCLIC COMPOUNDS AS AGONISTS FOR THE THYROID RECEPTOR | KARO BIO AB (SE) | 2008-03-19 | — | — | EP | disclosed |
| WO-2007003419-A1 | HETEROCYCLIC COMPOUNDS AS AGONISTS FOR THE THYROID RECEPTOR | KARO BIO AB (SE) | 2007-01-11 | — | — | WO | disclosed |