Known targets — ChEMBL curated mechanism
MMP1MMP13MMP7MMP8polrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Clopyralid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 5/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.45 |
| ▸ | MEN1 | O00255 | 3/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | CTSA | P10619 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Clopyralid SCHEMBL2403527 | 0.90 | KMT2A (0.49) | KMT2AL3MBTL1MEN1CYP2C9CYP2C19 | |
| Clopyralid SCHEMBL8535196 | 0.88 | KMT2A (0.50) | KMT2AL3MBTL1MEN1CYP2C9CYP2C19 | |
| Clopyralid SCHEMBL54779 | 0.88 | KMT2A (0.50) | KMT2AL3MBTL1MEN1CYP2C9CYP2C19 | |
| Clopyralid SCHEMBL29371357 | 0.88 | KMT2A (0.50) | KMT2AL3MBTL1MEN1CYP2C9CYP2C19 | |
| Clopyralid SCHEMBL1698170 | 0.86 | KMT2A (0.47) | KMT2ATDP1L3MBTL1MEN1CYP2C9 | |
| Clopyralid SCHEMBL20377277 | 0.86 | KMT2A (0.49) | KMT2AL3MBTL1MEN1CYP2C9CYP2C19 | |
| Clopyralid SCHEMBL5934004 | 0.86 | KMT2A (0.49) | KMT2AL3MBTL1MEN1CYP2C9CYP2C19 | |
| Clopyralid SCHEMBL726319 | 0.86 | KMT2A (0.49) | KMT2AL3MBTL1MEN1CYP2C9CYP2C19 | |
| Clopyralid SCHEMBL29256280 | 0.86 | KMT2A (0.49) | KMT2AL3MBTL1MEN1CYP2C9CYP2C19 | |
| Clopyralid SCHEMBL11270195 | 0.86 | KMT2A (0.49) | KMT2AL3MBTL1MEN1CYP2C9CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3054774-B1 | AQUEOUS HERBICIDAL CONCENTRATES | DOW AGROSCIENCES LLC (US) | 2021-01-27 | — | — | EP | disclosed |
| EP-3054774-A1 | AQUEOUS HERBICIDAL CONCENTRATES | Dow AgroSciences LLC (US) | 2016-08-17 | — | — | EP | disclosed |
| WO-2015054561-A1 | AQUEOUS HERBICIDAL CONCENTRATES | DOW AGROSCIENCES LLC (US) | 2015-04-16 | — | — | WO | disclosed |
| US-20150105254-A1 | AQUEOUS HERBICIDAL CONCENTRATES | DOW AGROSCIENCES LLC (US) | 2015-04-16 | — | — | US | disclosed |
| EP-1947939-A2 | IMPROVED CONTROL OF WOODY PLANTS BY THE FOLIAR APPLICATION OF TRICLOPYR BUTOXYETHYL ESTER COMPOSITIONS FREE OF AROMATIC SOLVENTS | Dow AgroSciences LLC (US) | 2008-07-30 | — | — | EP | disclosed |
| WO-2007061976-A2 | USE OF COMPOSITIONS COMPRISING TRICLOPYR BUTOXYETHYL ESTER FOR THE CONTROL OF WOODY PLANTS | DOW AGROSCIENCES LLC (US) | 2007-05-31 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150105254-A1 | AQUEOUS HERBICIDAL CONCENTRATES | DDT, AQP3, AQP1 | KMT2A 525/4885TDP1 619/4885L3MBTL1 1882/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.