Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 3/20 | 0.54 |
| ▸ | MAPT | P10636 | 2/20 | 0.54 |
| ▸ | CRHBP | P24387 | 2/20 | 0.53 |
| ▸ | CRHR2 | Q13324 | 2/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | KCNQ2 | O43526 | 2/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | THRB | P10828 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | USP2 | O75604 | 1/20 | 0.46 |
| ▸ | PPARG | P37231 | 1/20 | 0.46 |
| ▸ | NCOA2 | Q15596 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | PDE5A | O76074 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4956705 | 0.81 | POLB (0.53) | POLBMAPTCRHBPCRHR2SMN1; SMN2 | |
| SCHEMBL6173591 | 0.71 | CDK2 (0.61) | POLBMAPTCRHBPCRHR2SMN1; SMN2 | |
| SCHEMBL31062630 | 0.70 | POLB (0.55) | POLBMAPTCRHBPCRHR2SMN1; SMN2 | |
| SCHEMBL19074542 | 0.70 | ALDH1A1 (0.82) | POLBMAPTCRHBPCRHR2SMN1; SMN2 | |
| SCHEMBL7752354 | 0.70 | ALDH1A1 (0.82) | POLBMAPTCRHBPCRHR2SMN1; SMN2 | |
| SCHEMBL30216520 | 0.69 | POLB (0.54) | POLBMAPTCRHBPCRHR2SMN1; SMN2 | |
| SCHEMBL2753573 | 0.69 | POLB (0.60) | POLBMAPTCRHBPCRHR2SMN1; SMN2 | |
| SCHEMBL30216449 | 0.69 | ALDH1A1 (0.57) | POLBMAPTCRHBPCRHR2SMN1; SMN2 | |
| SCHEMBL2752637 | 0.68 | POLB (0.73) | POLBMAPTPDE5A | |
| SCHEMBL30216440 | 0.68 | KCNQ2 (0.54) | POLBMAPTCRHBPCRHR2SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080312291-A1 | Heterocyclic Gaba-b Modulators | ASTRAZENECA AB (SE) | 2008-12-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080312291-A1 | Heterocyclic Gaba-b Modulators | GABBR1, GABBR2, GABRB1 | POLB 3748/4885MAPT 3842/4885CRHBP 1352/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.