Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 19/20 | 0.46 |
| ▸ | AXL | P30530 | 1/20 | 0.42 |
| ▸ | MERTK | Q12866 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14312723 | 0.94 | RIPK1 (0.46) | RIPK1 | |
| SCHEMBL14312842 | 0.89 | RIPK1 (0.46) | RIPK1 | |
| SCHEMBL5076719 | 0.88 | ACVRL1 (0.42) | RIPK1 | |
| SCHEMBL16496878 | 0.88 | RIPK1 (0.43) | RIPK1 | |
| SCHEMBL14312544 | 0.87 | PIK3CD (0.43) | RIPK1 | |
| SCHEMBL14313043 | 0.87 | PIK3CD (0.52) | RIPK1 | |
| SCHEMBL14312843 | 0.86 | RIPK1 (0.43) | RIPK1 | |
| SCHEMBL5141007 | 0.86 | RIPK1 (0.46) | RIPK1 | |
| SCHEMBL5077230 | 0.86 | PIK3CD (0.47) | RIPK1 | |
| SCHEMBL5076831 | 0.85 | ACVRL1 (0.42) | RIPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1945222-A2 | PYRROLO[2,1-F] [1,2,4] TRIAZIN-4-YLAMINES IGF-1R KINASE INHIBITORS FOR THE TREATMENT OF CANCER AND OTHER HYPERPROLIFERATIVE DISEASES | Bayer HealthCare AG (DE) | 2008-07-23 | — | — | EP | disclosed |
| WO-2007056170-A2 | PYRROLO[2,1-F] [1,2,4] TRIAZIN-4-YLAMINES IGF-1R KINASE INHIBITORS FOR THE TREATMENT OF CANCER AND OTHER HYPERPROLIFERATIVE DISEASES | BAYER HEALTHCARE AG (DE) | 2007-05-18 | — | — | WO | disclosed |