Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRA | P10827 | 15/20 | 0.52 |
| ▸ | THRB | P10828 | 15/20 | 0.52 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.45 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.39 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.39 |
| ▸ | CYSLTR2 | Q9NS75 | 1/20 | 0.38 |
| ▸ | CYSLTR1 | Q9Y271 | 1/20 | 0.38 |
| ▸ | PPARG | P37231 | 1/20 | 0.37 |
| ▸ | PPARD | Q03181 | 1/20 | 0.37 |
| ▸ | PPARA | Q07869 | 1/20 | 0.37 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3133738 | 0.98 | THRA (0.54) | THRATHRBLTB4RFFAR1AKR1B1 | |
| SCHEMBL3141004 | 0.90 | THRA (0.53) | THRATHRBFFAR1AKR1B1PPARG | |
| SCHEMBL5077535 | 0.90 | THRA (0.41) | THRATHRBLTB4RPPARGPPARD | |
| SCHEMBL3140699 | 0.87 | THRA (0.54) | THRATHRBFFAR1AKR1B1 | |
| SCHEMBL3137369 | 0.81 | THRA (0.56) | THRATHRBFFAR1 | |
| SCHEMBL3145813 | 0.77 | THRA (0.52) | THRATHRBFFAR1 | |
| SCHEMBL3145893 | 0.77 | THRA (0.52) | THRATHRB | |
| SCHEMBL3136444 | 0.75 | THRA (0.50) | THRATHRB | |
| Propionic Acid SCHEMBL5136420 | 0.75 | THRA (0.52) | THRATHRBPPARD | |
| SCHEMBL7821052 | 0.73 | LTB4R (0.51) | LTB4RFFAR1CYSLTR2CYSLTR1PPARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1899309-A1 | HETEROCYCLIC COMPOUNDS AS AGONISTS FOR THE THYROID RECEPTOR | KARO BIO AB (SE) | 2008-03-19 | — | — | EP | disclosed |
| WO-2007003419-A1 | HETEROCYCLIC COMPOUNDS AS AGONISTS FOR THE THYROID RECEPTOR | KARO BIO AB (SE) | 2007-01-11 | — | — | WO | disclosed |