SCHEMBL5077541

SCHEMBL5077541

CCc1cc(C)c2cc(Cc3c(Br)cc(OCC(=O)OC(=O)C(F)Cc4cc(Br)c(Oc5cc(F)c6nc(CC)cc(C)c6c5)c(Br)c4)cc3Br)ccc2n1

nearest known ligand 0.33

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
THRA P10827 1/20 0.33
THRB P10828 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5077538 0.91 THRB (0.39) THRATHRB
SCHEMBL3133494 0.79 THRA (0.38) THRATHRB
SCHEMBL5074394 0.77 THRA (0.32) THRATHRB
SCHEMBL3131792 0.75 THRB (0.53) THRATHRB
SCHEMBL3136450 0.74 THRA (0.38) THRATHRB
SCHEMBL3141250 0.72 THRA (0.37) THRATHRB
Propionic Acid SCHEMBL5074391 0.72 THRA (0.35) THRATHRB
SCHEMBL3142284 0.69 THRB (0.34) THRATHRB
SCHEMBL3133511 0.69 THRB (0.51) THRATHRB
SCHEMBL3140915 0.68 THRA (0.38) THRATHRB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1899309-A1 HETEROCYCLIC COMPOUNDS AS AGONISTS FOR THE THYROID RECEPTOR KARO BIO AB (SE) 2008-03-19 EP disclosed
WO-2007003419-A1 HETEROCYCLIC COMPOUNDS AS AGONISTS FOR THE THYROID RECEPTOR KARO BIO AB (SE) 2007-01-11 WO disclosed