Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of 1-Naphthol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 2/20 | 0.68 |
| ▸ | HTR1B | P28222 | 2/20 | 0.49 |
| ▸ | IDO1 | P14902 | 3/20 | 0.47 |
| ▸ | CCR4 | P51679 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | PTPN22 | Q9Y2R2 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | PLAU | P00749 | 1/20 | 0.41 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.41 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.41 |
| ▸ | NQO2 | P16083 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.41 |
| ▸ | APP | P05067 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| 1-Naphthol SCHEMBL2481329 | 0.85 | CYP1A2 (0.77) | CYP1A2IDO1HSD17B10CYP2C9CYP2C19 | |
| 1-Naphthol SCHEMBL27983786 | 0.83 | CYP1A2 (0.74) | CYP1A2IDO1HSD17B10CYP2C9CYP2C19 | |
| 1-Naphthol SCHEMBL28476693 | 0.83 | CYP1A2 (0.74) | CYP1A2IDO1HSD17B10CYP2C9CYP2C19 | |
| 1-Naphthol SCHEMBL10414647 | 0.83 | CYP1A2 (0.81) | CYP1A2IDO1HSD17B10CYP2C9CYP2C19 | |
| 1-Naphthol SCHEMBL10627914 | 0.83 | CYP1A2 (0.90) | CYP1A2IDO1HSD17B10CYP2C9CYP2C19 | |
| 1-Naphthol SCHEMBL273260 | 0.82 | CYP1A2 (1.00) | CYP1A2IDO1HSD17B10CYP2C9CYP2C19 | |
| 1-Naphthol SCHEMBL29767730 | 0.82 | CYP1A2 (1.00) | CYP1A2IDO1HSD17B10CYP2C9CYP2C19 | |
| 1-Naphthol SCHEMBL10486461 | 0.82 | CYP1A2 (1.00) | CYP1A2IDO1HSD17B10CYP2C9CYP2C19 | |
| 1-Naphthol SCHEMBL3416 | 0.82 | CYP1A2 (1.00) | CYP1A2IDO1HSD17B10CYP2C9CYP2C19 | |
| 1-Naphthol SCHEMBL28331152 | 0.82 | CYP1A2 (0.65) | CYP1A2IDO1HSD17B10CYP2C9CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1271133-B1 | Method of measurement based on fluorescence energy transfer using a long-lived fluorescence donor | DAIICHI PURE CHEMICALS CO LTD (JP) | 2008-05-28 | — | — | EP | disclosed |
| US-20060252099-A1 | Method for measurement by using long-lived excitation fluorescence | DAIICHI PURE CHEMICALS CO., LTD. (JP) | 2006-11-09 | — | — | US | disclosed |
| US-20030157727-A1 | Measuring method using long life fluorescence of excitation type | DAIICHI PURE CHEMICALS CO., LTD. (JP) | 2003-08-21 | — | — | US | disclosed |
| EP-1271133-A1 | MEASURING METHOD USING LONG LIFE FLUORESCENCE OF EXCITATION TYPE | DAIICHI PURE CHEMICALS CO., LTD. (JP) | 2003-01-02 | — | — | EP | disclosed |