SCHEMBL5079128

SCHEMBL5079128

O=C(O)CC1=COc2ccccc2C=N1

nearest known ligand 0.47

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
TRPA1 O75762 7/20 0.39
AKR1B1 P15121 2/20 0.37
LMNA P02545 2/20 0.33
HTT P42858 2/20 0.33
ABCC4 O15439 1/20 0.33
GAA P10253 1/20 0.33
TSHR P16473 1/20 0.33
PTGS1 P23219 1/20 0.33
NR4A1 P22736 1/20 0.32
NR4A2 P43354 1/20 0.32
NR4A3 Q92570 1/20 0.32
HPGD P15428 1/20 0.32
ALOX15 P16050 1/20 0.32
MAPK1 P28482 1/20 0.32
HSD17B10 Q99714 1/20 0.32
KDM4E B2RXH2 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6190912 0.86 TRPA1 (0.42) TRPA1
SCHEMBL4563592 0.75 LMNA (0.39) TRPA1LMNA
SCHEMBL29381688 0.69 AKR1B1 (0.36) AKR1B1LMNAHTTABCC4GAA
SCHEMBL28760202 0.65 TRPA1 (0.41) TRPA1
SCHEMBL31495896 0.64 TRPA1 (0.43) TRPA1LMNAHTTHPGDALOX15
SCHEMBL23573691 0.62 TRPA1 (0.46) TRPA1LMNAHTTHPGDALOX15
SCHEMBL23573692 0.62 TRPA1 (0.46) TRPA1LMNAHTTHPGDALOX15
SCHEMBL2801646 0.62 AKR1B1 (0.39) AKR1B1LMNAHTTABCC4GAA
SCHEMBL8665717 0.61 AKR1B1 (0.38) AKR1B1LMNAHTTABCC4GAA
SCHEMBL8665718 0.59 ALOX5 (0.49) AKR1B1GAAPTGS1HPGDKDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1962832-A2 COMBINATIONS OF A QUALENE SYNTHASE INHIBITOR AND A HMG-COA REDUCTASE INHIBITOR FOR TREATING HYPERLIPIDEMIA Takeda Pharmaceutical Company Limited (JP) 2008-09-03 EP disclosed
EP-1776096-A2 CRP LOWERING AGENT Takeda Pharmaceutical Company Limited (JP) 2007-04-25 EP disclosed
EP-1753752-A1 HIGHLY SELECTIVE NOVEL AMIDATION METHOD Takeda Pharmaceutical Company Limited (JP) 2007-02-21 EP disclosed
WO-2006129859-A2 COMBINATIONS OF A SQUALENE SYNTHASE INHIBITOR AND A HMG-COA REDUCTASE INHIBITOR FOR TREATING HYPERLIPIDEMIA TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2006-12-07 WO disclosed
WO-2006016681-A2 CRP LOWERING AGENT TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2006-02-16 WO disclosed
WO-2005121133-A1 HIGHLY SELECTIVE NOVEL AMIDATION METHOD TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2005-12-22 WO disclosed
EP-1292585-A1 BENZOXAZEPINONES AND THEIR USE AS SQUALENE SYNTHASE INHIBITORS Takeda Chemical Industries, Ltd. (JP) 2003-03-19 EP disclosed
WO-2001098282-A1 BENZOXAZEPINONES AND THEIR USE AS SQUALENE SYNTHASE INHIBITORS TAKEDA CHEMICAL INDUSTRIES, LTD (JP) 2001-12-27 WO disclosed
EP-0979227-A1 4,1-BENZOXAZEPINES, THEIR ANALOGUES, AND THEIR USE AS SOMATOSTATIN AGONISTS Takeda Chemical Industries, Ltd. (JP) 2000-02-16 EP disclosed
WO-1998047882-A1 4,1-BENZOXAZEPINES, THEIR ANALOGUES, AND THEIR USE AS SOMATOSTATIN AGONISTS TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1998-10-29 WO disclosed
EP-0862562-A1 BENZOXAZEPINE COMPOUNDS, THEIR PRODUCTION AND USE AS LIPID LOWERING AGENTS Takeda Chemical Industries, Ltd. (JP) 1998-09-09 EP disclosed
WO-1997010224-A1 BENZOXAZEPINE COMPOUNDS, THEIR PRODUCTION AND USE AS LIPID LOWERING AGENTS TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1997-03-20 WO disclosed
WO-1995021834-A1 OPTICALLY ACTIVE 4,1-BENZOXAZEPINE DERIVATIVES USEFUL AS SQUALENE SYNTHASE INHIBITORS TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1995-08-17 WO disclosed