Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 6/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | NEK2 | P51955 | 2/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | TNK2 | Q07912 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 2/20 | 0.34 |
| ▸ | RAB9A | P51151 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | GRK5 | P34947 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.33 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.33 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.33 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.33 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.33 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.33 |
| ▸ | LATS1 | O95835 | 1/20 | 0.33 |
| ▸ | INSR | P06213 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5082589 | 0.88 | IGF1R (0.41) | IGF1RSMN1; SMN2NEK2TNK2NPC1 | |
| SCHEMBL5082616 | 0.86 | IGF1R (0.36) | IGF1RNEK2CYP3A4NPC1RAB9A | |
| SCHEMBL5080636 | 0.81 | IGF1R (0.48) | IGF1RCYP3A4TNK2KDM4EMAPT | |
| SCHEMBL5084882 | 0.81 | IGF1R (0.48) | IGF1RSMN1; SMN2CYP3A4TNK2NPC1 | |
| SCHEMBL3040790 | 0.80 | IGF1R (0.51) | IGF1RNEK2CYP3A4TNK2NPC1 | |
| SCHEMBL402472 | 0.79 | IGF1R (0.79) | IGF1RNEK2CYP3A4TNK2RIPK2 | |
| SCHEMBL4073244 | 0.78 | IGF1R (0.51) | IGF1RNEK2CYP3A4TNK2RIPK2 | |
| SCHEMBL400198 | 0.77 | IGF1R (0.61) | IGF1RCYP3A4TNK2RIPK2INSR | |
| SCHEMBL5086965 | 0.76 | IGF1R (0.43) | IGF1RTNK2KDM4EALDH1A1HSD17B10 | |
| SCHEMBL5085373 | 0.73 | IGF1R (0.43) | IGF1RCYP3A4TNK2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1979002-A2 | COMBINATION OF IGFR INHIBITOR AND ANTI-CANCER AGENT | OSI Pharmaceuticals, Inc. (US) | 2008-10-15 | — | — | EP | disclosed |
| WO-2007075554-A2 | COMBINATION OF IGFR INHIBITOR AND ANTI-CANCER AGENT | OSI PHARMACEUTICALS, INC. (US) | 2007-07-05 | — | — | WO | disclosed |