Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 3/20 | 0.43 |
| ▸ | TNK2 | Q07912 | 2/20 | 0.37 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.34 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | ABL1 | P00519 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | DHFR | P00374 | 1/20 | 0.33 |
| ▸ | CFTR | P13569 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.33 |
| ▸ | BTK | Q06187 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5083298 | 0.85 | IGF1R (0.40) | IGF1RTNK2TGFBR1MEN1KMT2A | |
| SCHEMBL5086140 | 0.85 | TNK2 (0.45) | IGF1RTNK2KDM4EALDH1A1HPGD | |
| SCHEMBL400649 | 0.80 | IGF1R (0.69) | IGF1RTNK2BTK | |
| SCHEMBL3040790 | 0.80 | IGF1R (0.51) | IGF1RTNK2POLBHPGD | |
| SCHEMBL401018 | 0.79 | TNK2 (0.38) | IGF1RTNK2LMNAKDM4EALDH1A1 | |
| SCHEMBL1566947 | 0.79 | TNK2 (0.38) | IGF1RTNK2LMNAKDM4EALDH1A1 | |
| SCHEMBL5262952 | 0.79 | IGF1R (0.39) | IGF1RLMNAKDM4EALDH1A1MAPT | |
| SCHEMBL5085373 | 0.78 | IGF1R (0.43) | IGF1RTNK2MEN1KMT2AABL1 | |
| SCHEMBL5080636 | 0.76 | IGF1R (0.48) | IGF1RTNK2ABL1POLBKDM4E | |
| SCHEMBL5084882 | 0.76 | IGF1R (0.48) | IGF1RTNK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008076143-A1 | COMBINATION OF IGFR INHIBITOR AND ANTI-CANCER AGENT | OSI PHARMACEUTICALS, INC. (US) | 2008-06-26 | — | — | WO | disclosed |