Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 4/20 | 0.48 |
| ▸ | TNK2 | Q07912 | 2/20 | 0.39 |
| ▸ | ATR | Q13535 | 2/20 | 0.37 |
| ▸ | CSF1R | P07333 | 2/20 | 0.37 |
| ▸ | ABL1 | P00519 | 1/20 | 0.36 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.36 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.36 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | GSK3B | P49841 | 1/20 | 0.34 |
| ▸ | JAK2 | O60674 | 1/20 | 0.34 |
| ▸ | PIP5K1C | O60331 | 1/20 | 0.34 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | ACVRL1 | P37023 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5083787 | 0.91 | TNK2 (0.42) | IGF1RTNK2ABL1ADORA2AADORA1 | |
| SCHEMBL5083298 | 0.88 | IGF1R (0.40) | IGF1RTNK2ATRCSF1RADORA2A | |
| SCHEMBL5087010 | 0.88 | IGF1R (0.39) | IGF1RTNK2ATRABL1GSK3B | |
| SCHEMBL5080364 | 0.86 | IGF1R (0.36) | IGF1RTNK2ADORA2AADORA1CYP3A4 | |
| SCHEMBL5084882 | 0.84 | IGF1R (0.48) | IGF1RTNK2CYP3A4 | |
| SCHEMBL3040790 | 0.82 | IGF1R (0.51) | IGF1RTNK2ATRADORA2AADORA1 | |
| SCHEMBL5079162 | 0.81 | IGF1R (0.50) | IGF1RTNK2CYP3A4KDM4EMAPT | |
| SCHEMBL4073244 | 0.80 | IGF1R (0.51) | IGF1RTNK2CYP3A4 | |
| SCHEMBL400874 | 0.77 | IGF1R (0.77) | IGF1RTNK2CYP3A4 | |
| SCHEMBL5086076 | 0.77 | IGF1R (0.44) | IGF1RTNK2ABL1ADORA2AADORA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008076143-A1 | COMBINATION OF IGFR INHIBITOR AND ANTI-CANCER AGENT | OSI PHARMACEUTICALS, INC. (US) | 2008-06-26 | — | — | WO | claimed |