Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 3/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | NEK2 | P51955 | 1/20 | 0.35 |
| ▸ | ABL1 | P00519 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | RECQL | P46063 | 1/20 | 0.32 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.32 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.32 |
| ▸ | MEN1 | O00255 | 4/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.32 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.31 |
| ▸ | TNK2 | Q07912 | 1/20 | 0.31 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.31 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.30 |
| ▸ | HPGD | P15428 | 3/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5079162 | 0.88 | IGF1R (0.50) | IGF1RSMN1; SMN2NEK2LMNAHTT | |
| SCHEMBL5085373 | 0.86 | IGF1R (0.43) | IGF1RABL1LMNAMEN1KMT2A | |
| SCHEMBL5081252 | 0.82 | TNK2 (0.42) | IGF1RABL1TNK2 | |
| SCHEMBL5087010 | 0.82 | IGF1R (0.39) | IGF1RABL1KDM4EMEN1KMT2A | |
| SCHEMBL399341 | 0.80 | IGF1R (0.62) | IGF1RTNK2 | |
| SCHEMBL399520 | 0.74 | RIPK2 (0.42) | IGF1RABL1KCNH2 | |
| SCHEMBL5083797 | 0.73 | IGF1R (0.38) | IGF1RNEK2TNK2 | |
| SCHEMBL5082616 | 0.73 | IGF1R (0.36) | IGF1RNEK2KDM4EALDH1A1NPC1 | |
| SCHEMBL400087 | 0.72 | KDR (0.43) | IGF1RABL1 | |
| Carbamic Acid SCHEMBL4066334 | 0.71 | TNK2 (0.54) | IGF1RTNK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008076143-A1 | COMBINATION OF IGFR INHIBITOR AND ANTI-CANCER AGENT | OSI PHARMACEUTICALS, INC. (US) | 2008-06-26 | — | — | WO | disclosed |