Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 1/20 | 0.42 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.42 |
| ▸ | CCNB2 | O95067 | 8/20 | 0.41 |
| ▸ | CDK1 | P06493 | 8/20 | 0.41 |
| ▸ | CCNB1 | P14635 | 8/20 | 0.41 |
| ▸ | CCNB3 | Q8WWL7 | 8/20 | 0.41 |
| ▸ | CDK2 | P24941 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 3/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.38 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5080062 | 0.88 | CDK1 (0.45) | CCNB2CDK1CCNB1CCNB3CDK2 | |
| SCHEMBL5086065 | 0.86 | ABL1 (0.38) | ABL1RIN1CCNB2CDK1CCNB1 | |
| SCHEMBL5085944 | 0.85 | LMNA (0.42) | CCNB2CDK1CCNB1CCNB3CDK2 | |
| SCHEMBL6055218 | 0.85 | CDK1 (0.39) | CCNB2CDK1CCNB1CCNB3CDK2 | |
| SCHEMBL5082994 | 0.83 | ABL1 (0.42) | ABL1RIN1CCNB2CDK1CCNB1 | |
| SCHEMBL5082970 | 0.81 | NR2F2 (0.43) | ABL1RIN1 | |
| SCHEMBL5083017 | 0.81 | ADORA1 (0.43) | ABL1RIN1HTTTP53TSHR | |
| SCHEMBL14175344 | 0.79 | CDK1 (0.42) | CCNB2CDK1CCNB1CCNB3CDK2 | |
| SCHEMBL5082274 | 0.77 | LMNA (0.39) | CCNB2CDK1CCNB1CCNB3CDK2 | |
| SCHEMBL5083593 | 0.77 | DUT (0.38) | CCNB2CDK1CCNB1CCNB3CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7388002-B2 | Nucleosides, preparation thereof and use as inhibitors of RNA viral polymerases | BIOCRYST PHARMACEUTICALS, INC. (US) | 2008-06-17 | — | — | US | disclosed |
| US-20060122391-A1 | Nucleosides, preparation thereof and use as inhibitors of RNA viral polymerases | BIOCRYST PHARMACEUTICALS, INC. (US) | 2006-06-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060122391-A1 | Nucleosides, preparation thereof and use as inhibitors of RNA viral polymerases | POLR2H, NSUN2, POLR2E | ABL1 2347/4885RIN1 1635/4885CCNB2 428/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.