Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 5/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.56 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.48 |
| ▸ | HBB | P68871 | 1/20 | 0.48 |
| ▸ | ESR1 | P03372 | 1/20 | 0.44 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.41 |
| ▸ | NT5E | P21589 | 1/20 | 0.40 |
| ▸ | P2RY6 | Q15077 | 1/20 | 0.40 |
| ▸ | P2RY14 | Q15391 | 1/20 | 0.40 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.39 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | ALB | P02768 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | BLM | P54132 | 1/20 | 0.39 |
| ▸ | TK1 | P04183 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5080168 | 1.00 | LMNA (0.56) | LMNASMN1; SMN2MAPTTSHRPMP22 | |
| SCHEMBL5079307 | 0.81 | LMNA (0.39) | LMNASMN1; SMN2TSHRPMP22ADRA1A | |
| SCHEMBL5076808 | 0.78 | LMNA (0.56) | LMNASMN1; SMN2MAPTTSHRPMP22 | |
| SCHEMBL5076805 | 0.78 | LMNA (0.56) | LMNASMN1; SMN2MAPTTSHRPMP22 | |
| SCHEMBL7116228 | 0.77 | LMNA (0.52) | LMNASMN1; SMN2MAPTTSHRPMP22 | |
| SCHEMBL7116224 | 0.77 | LMNA (0.52) | LMNASMN1; SMN2MAPTTSHRPMP22 | |
| SCHEMBL23590325 | 0.76 | LMNA (0.51) | LMNASMN1; SMN2MAPTTSHRPMP22 | |
| SCHEMBL12595726 | 0.74 | LMNA (0.65) | LMNASMN1; SMN2MAPTTSHRPMP22 | |
| SCHEMBL9123486 | 0.74 | LMNA (0.58) | LMNASMN1; SMN2MAPTTSHRPMP22 | |
| SCHEMBL9123491 | 0.74 | LMNA (0.58) | LMNASMN1; SMN2MAPTTSHRPMP22 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080293668-A1 | [5-carboxamido or 5-fluoro]-[2',3'-unsaturated or 3'-modified]-pyrimidine nucleosides | SCHINAZI RAYMOND F | 2008-11-27 | — | — | US | claimed |
| US-20040167140-A1 | [5-carboxamido or 5-fluoro]-[2',3'-unsaturated or 3'-modified]-pyrimidine nucleosides | EMORY UNIVERSITY | 2004-08-26 | — | — | US | claimed |
| EP-1361227-A2 | [5-carboxamide or 5-fluoro]-[2', 3'-unsaturated or 3'-modifield]-pyrimidine nucleosides | Emory University (US) | 2003-11-12 | — | — | EP | claimed |
| US-20020198173-A1 | [5-carboxamido or 5-fluoro] - [2' ,3' -unsaturated or 3' -modified] - pyrimidine nucleosides | EMORY UNIVERSITY | 2002-12-26 | — | — | US | claimed |
| US-20080293668-A1 | [5-carboxamido or 5-fluoro]-[2',3'-unsaturated or 3'-modified]-pyrimidine nucleosides | SCHINAZI RAYMOND F | 2008-11-27 | — | — | US | disclosed |
| US-7419966-B2 | [5-carboxamido or 5-fluoro]-[2′,3′-unsaturated or 3′-modified]-pyrimidine nucleosides | EMORY UNIVERSITY (US) | 2008-09-02 | — | — | US | disclosed |
| US-20040167140-A1 | [5-carboxamido or 5-fluoro]-[2',3'-unsaturated or 3'-modified]-pyrimidine nucleosides | EMORY UNIVERSITY | 2004-08-26 | — | — | US | disclosed |
| US-6680303-B2 | VIRICIDES FOR TREATING HIV AND HEPATITIS VIRUS | EMORY UNIVERSITY | 2004-01-20 | — | — | US | disclosed |
| EP-1361227-A2 | [5-carboxamide or 5-fluoro]-[2', 3'-unsaturated or 3'-modifield]-pyrimidine nucleosides | Emory University (US) | 2003-11-12 | — | — | EP | disclosed |
| US-20020198173-A1 | [5-carboxamido or 5-fluoro] - [2' ,3' -unsaturated or 3' -modified] - pyrimidine nucleosides | EMORY UNIVERSITY | 2002-12-26 | — | — | US | disclosed |
| US-6391859-B1 | HUMAN IMMUNODEFICIENCY VIRUS; VIRICIDES | EMORY UNIVERSITY | 2002-05-21 | — | — | US | disclosed |
| US-6232300-B1 | ADMINISTERING AS HEPATITIS B VIRICIDE | EMORY UNIVERSITY | 2001-05-15 | — | — | US | disclosed |
| US-5905070-A | HUMAN T-CELL LEUKEMIA/LYMPHOMA AND HEPATITIS B VIRICIDES; AIDS | EMORY UNIVERSITY (US) | 1999-05-18 | — | — | US | disclosed |
| US-5703058-A | TREATMENT OF HIV AND HEPATITIS B | EMORY UNIVERSITY (US) | 1997-12-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080293668-A1 | [5-carboxamido or 5-fluoro]-[2',3'-unsaturated or 3'-modified]-pyrimidine nucleosides | DUT, NUDT1, PNP | LMNA 1598/4885SMN1; SMN2 1959/4885MAPT 3122/4885 |
| US-20020198173-A1 | [5-carboxamido or 5-fluoro] - [2' ,3' -unsaturated or 3' -modified] - pyrimidine nucleosides | DUT, NUDT1, PNP | LMNA 1735/4885SMN1; SMN2 1970/4885MAPT 3027/4885 |
| US-20040167140-A1 | [5-carboxamido or 5-fluoro]-[2',3'-unsaturated or 3'-modified]-pyrimidine nucleosides | DUT, NUDT1, PNP | LMNA 1735/4885SMN1; SMN2 1970/4885MAPT 3027/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.