Known targets — ChEMBL curated mechanism
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
The experimentally established mechanism targets of Phosphoric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.36 |
| ▸ | HSP90AB1 | P08238 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.36 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | MIF | P14174 | 1/20 | 0.36 |
| ▸ | TYR | P14679 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | ATP2A2 | P16615 | 1/20 | 0.33 |
| ▸ | ATP2A3 | Q93084 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29406783 | 0.91 | ALDH1A1 (0.42) | HSP90AA1HSP90AB1ALDH1A1CYP2C9ALOX15 | |
| SCHEMBL7625000 | 0.91 | ALDH1A1 (0.42) | HSP90AA1HSP90AB1ALDH1A1CYP2C9ALOX15 | |
| Phosphoric Acid SCHEMBL5557414 | 0.90 | HSP90AA1 (0.35) | HSP90AA1HSP90AB1ALDH1A1CYP2C9ALOX15 | |
| Phosphoric Acid SCHEMBL9516746 | 0.90 | HSP90AA1 (0.35) | HSP90AA1HSP90AB1ALDH1A1CYP2C9ALOX15 | |
| SCHEMBL29391738 | 0.89 | ALDH1A1 (0.41) | HSP90AA1HSP90AB1ALDH1A1CYP2C9ALOX15 | |
| SCHEMBL5080249 | 0.85 | INPPL1 (0.37) | HSP90AA1HSP90AB1 | |
| SCHEMBL5557410 | 0.84 | INPPL1 (0.36) | HSP90AA1HSP90AB1 | |
| Phosphoric Acid SCHEMBL8630742 | 0.82 | ALDH1A1 (0.41) | HSP90AA1HSP90AB1ALDH1A1CYP2C9ALOX15 | |
| SCHEMBL5179960 | 0.81 | HSP90AA1 (0.30) | HSP90AA1HSP90AB1 | |
| SCHEMBL30951029 | 0.81 | HSP90AA1 (0.30) | HSP90AA1HSP90AB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5653693-A | OBTAINED BY MOLDING PROPYLENE RESIN COMPOSITION AND PHOSPHORIC ESTER NUCLEATING AGENT; SYRINGE IS PREFILLED WITH DRUG | DAIICHI PHARMACEUTICAL CO., LTD. (JP) | 1997-08-05 | — | — | US | claimed |
| EP-0265075-B1 | POLYPROPYLENE RESIN COMPOSITION | MITSUI TOATSU CHEMICALS, Inc. (JP) | 1991-11-13 | — | — | EP | claimed |
| US-7462307-B2 | Singlelayer and multilayer polyolefin foam pipes | BOREALIS GMBH (AT) | 2008-12-09 | — | — | US | disclosed |
| US-20060233989-A1 | Singlelayer and multilayer polyolefin foam pipes | HESSE ACHIM | 2006-10-19 | — | — | US | disclosed |
| US-6986922-B2 | For ransporting crude oil or gas products; for insulation purposes and for non- or low-pressure applications and multilayer plastic pipes for the transportation of hot or cold fluids | BOREALIS GMBH (AT) | 2006-01-17 | — | — | US | disclosed |
| EP-1301343-B1 | SINGLELAYER AND MULTILAYER POLYOLEFIN FOAM PIPES | BOREALIS GMBH (AT) | 2004-04-21 | — | — | EP | disclosed |
| US-20030157286-A1 | Singlelayer and multilayer polyolefin foam pipes | BREDERO SHAW NORWAY AS (NO) | 2003-08-21 | — | — | US | disclosed |
| EP-1323779-A1 | Foamed polyolefin sheets with improved property spectrum | Borealis GmbH (AT) | 2003-07-02 | — | — | EP | disclosed |
| EP-1301343-A1 | SINGLELAYER AND MULTILAYER POLYOLEFIN FOAM PIPES | Borealis GmbH (AT) | 2003-04-16 | — | — | EP | disclosed |
| WO-2002007969-A1 | SINGLELAYER AND MULTILAYER POLYOLEFIN FOAM PIPES | BOREALIS GMBH (AT) | 2002-01-31 | — | — | WO | disclosed |
| EP-1174261-A1 | Single and multilayer polyolefin foam pipes | Borcalis GmbH (AT) | 2002-01-23 | — | — | EP | disclosed |
| US-6339123-B1 | FOR PRODUCING FILMS, SHEETS, FIBERS, PANELS, COATINGS, INJECTION MOLDED ARTICLE, PIPES, HOLLOW OBJECTS AND FOAMS | BOREALIS GMBH (AT) | 2002-01-15 | — | — | US | disclosed |
| US-6300257-B1 | Extrusion-coated nonwoven sheeting | BOREALIS AG (AT) | 2001-10-09 | — | — | US | disclosed |
| US-6242525-B1 | PROPYLENE HOMOPOLYMERS AND/OR COPOLYMERS WITH ELASTOMERS OF READILY VOLATILE DIENES IN THE PRESENCE OF THERMALLY DECOMPOSING FREE RADICAL-FORMING AGENTS; THERMOPLASTIC ELASTOMERS WITH A FINE DISPERSION DISTRIBUTION | BOREALIS GMBH (AT) | 2001-06-05 | — | — | US | disclosed |
| US-6235658-B1 | Composite with a textile character | BOREALIS GMBH (AT) | 2001-05-22 | — | — | US | disclosed |