Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.36 |
| ▸ | HBB | P68871 | 1/20 | 0.36 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.35 |
| ▸ | ESR1 | P03372 | 1/20 | 0.33 |
| ▸ | TYMS | P04818 | 1/20 | 0.33 |
| ▸ | RNASE1 | P07998 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.31 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.31 |
| ▸ | GRIA3 | P42263 | 1/20 | 0.31 |
| ▸ | GRIA4 | P48058 | 1/20 | 0.31 |
| ▸ | GRIK5 | Q16478 | 1/20 | 0.31 |
| ▸ | NT5E | P21589 | 1/20 | 0.30 |
| ▸ | P2RY6 | Q15077 | 1/20 | 0.30 |
| ▸ | P2RY14 | Q15391 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9223581 | 0.88 | RNASE1 (0.44) | LMNARNASE1 | |
| SCHEMBL5610629 | 0.87 | RNASE1 (0.32) | RNASE1 | |
| SCHEMBL9221120 | 0.83 | NT5E (0.36) | NT5EP2RY6 | |
| SCHEMBL6256517 | 0.83 | NT5E (0.36) | NT5EP2RY6 | |
| SCHEMBL7868482 | 0.82 | LMNA (0.43) | LMNASMN1; SMN2MAPTTSHRPMP22 | |
| SCHEMBL794862 | 0.81 | P2RY2 (0.31) | MAPTP2RY6 | |
| SCHEMBL10458072 | 0.81 | LMNA (0.39) | LMNASMN1; SMN2MAPTTSHRPMP22 | |
| SCHEMBL2014365 | 0.75 | CYP3A4 (0.38) | NT5E | |
| SCHEMBL20822313 | 0.75 | CYP3A4 (0.38) | NT5E | |
| SCHEMBL8367093 | 0.74 | SMN1; SMN2 (0.33) | SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080050425-A1 | Combination Chemotherapy Comprising 5-Fluorouracil or a Derivative Thereof and a Liposomal Platinum Complex | ANTIGENICS, INC. | 2008-02-28 | — | — | US | disclosed |
| EP-1631301-A4 | COMBINATION CHEMOTHERAPY COMPRISING 5-FLUOROURACIL OR A DERIVATIVE THEREOF AND A LIPOSOMAL PLATINUM COMPLEX | ARONEX PHARMACEUTICALS INC (US) | 2006-06-07 | — | — | EP | disclosed |
| EP-1631301-A1 | COMBINATION CHEMOTHERAPY COMPRISING 5-FLUOROURACIL OR A DERIVATIVE THEREOF AND A LIPOSOMAL PLATINUM COMPLEX | Aronex Pharmaceuticals Inc. (US) | 2006-03-08 | — | — | EP | disclosed |
| WO-2004103382-A1 | COMBINATION CHEMOTHERAPY COMPRISING 5-FLUOROURACIL OR A DERIVATIVE THEREOF AND A LIPOSOMAL PLATINUM COMPLEX | ARONEX PHARMACEUTICALS, INC. (US) | 2004-12-02 | — | — | WO | disclosed |
| US-4122251-A | Process for production of 5-fluorouracil and its derivatives | DAIKIN KOGYO CO., LTD. (JP) | 1978-10-24 | — | — | US | disclosed |