Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of 2-Phenylquinoline. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AR | P10275 | 2/20 | 0.67 |
| ▸ | NPC1 | O15118 | 8/20 | 0.63 |
| ▸ | RAB9A | P51151 | 8/20 | 0.63 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.63 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.63 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.63 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.63 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.63 |
| ▸ | MEN1 | O00255 | 2/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.59 |
| ▸ | MAPT | P10636 | 3/20 | 0.59 |
| ▸ | GMNN | O75496 | 1/20 | 0.59 |
| ▸ | TP53 | P04637 | 1/20 | 0.59 |
| ▸ | PKM | P14618 | 1/20 | 0.59 |
| ▸ | HPGD | P15428 | 1/20 | 0.59 |
| ▸ | THPO | P40225 | 1/20 | 0.59 |
| ▸ | BLM | P54132 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| 2-Phenylquinoline SCHEMBL44999 | 0.92 | RAB9A (0.73) | ARNPC1RAB9ACYP3A4CYP2C9 | |
| 2-Phenylquinoline SCHEMBL29399739 | 0.92 | RAB9A (0.73) | ARNPC1RAB9ACYP3A4CYP2C9 | |
| 2-Phenylquinoline SCHEMBL1815021 | 0.90 | RAB9A (0.70) | ARNPC1RAB9ACYP3A4CYP2C9 | |
| 2-Phenylquinoline SCHEMBL6858671 | 0.90 | RAB9A (0.70) | ARNPC1RAB9ACYP3A4CYP2C9 | |
| 2-Phenylquinoline SCHEMBL28871326 | 0.90 | RAB9A (0.70) | ARNPC1RAB9ACYP3A4CYP2C9 | |
| 2-Phenylquinoline SCHEMBL5733254 | 0.90 | RAB9A (0.70) | ARNPC1RAB9ACYP3A4CYP2C9 | |
| 2-Phenylquinoline SCHEMBL29986142 | 0.90 | RAB9A (0.70) | ARNPC1RAB9ACYP3A4CYP2C9 | |
| 2-Phenylquinoline SCHEMBL346742 | 0.90 | RAB9A (0.70) | ARNPC1RAB9ACYP3A4CYP2C9 | |
| 2-Phenylquinoline SCHEMBL29498037 | 0.90 | RAB9A (0.70) | ARNPC1RAB9ACYP3A4CYP2C9 | |
| 2-Phenylquinoline SCHEMBL668531 | 0.90 | RAB9A (0.70) | ARNPC1RAB9ACYP3A4CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0261426-B1 | FREEZE-DRIED PHARMACEUTICAL COMPOSITIONS OF PHENYLQUINOLINE CARBOXYLIC ACIDS | THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) | 1992-11-04 | — | — | EP | claimed |
| EP-0036145-B1 | AN ORALLY ADMINISTERED DRUG FORM COMPRISING A POLAR BIOACTIVE AGENT AND AN ADJUVANT | INTERx RESEARCH CORPORATION (US) | 1985-05-29 | — | — | EP | claimed |
| US-7335411-B2 | Method of producing a tire composition having improved silica reinforcement | BRIDGESTONE CORPORATION (JP) | 2008-02-26 | — | — | US | disclosed |
| US-20060089446-A1 | Method of producing a tire composition having improved silica reinforcement | BRIDGESTONE CORPORATION | 2006-04-27 | — | — | US | disclosed |