Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 6/20 | 0.44 |
| ▸ | TNK2 | Q07912 | 1/20 | 0.43 |
| ▸ | JAK2 | O60674 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | NEK2 | P51955 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.36 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.36 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.36 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.36 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.36 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.36 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.36 |
| ▸ | KDR | P35968 | 1/20 | 0.36 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.35 |
| ▸ | CYP46A1 | Q9Y6A2 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3040790 | 0.90 | IGF1R (0.51) | IGF1RTNK2JAK2POLBHPGD | |
| SCHEMBL5086076 | 0.88 | IGF1R (0.44) | IGF1RTNK2JAK2HPGDADORA3 | |
| SCHEMBL5083787 | 0.83 | TNK2 (0.42) | IGF1RTNK2JAK2HPGDADORA2A | |
| SCHEMBL5086253 | 0.83 | TNK2 (0.50) | IGF1RTNK2 | |
| SCHEMBL4073244 | 0.81 | IGF1R (0.51) | IGF1RTNK2NEK2FGFR1KDR | |
| SCHEMBL396313 | 0.79 | TNK2 (0.68) | IGF1RTNK2NEK2FGFR1KDR | |
| SCHEMBL3896776 | 0.77 | IGF1R (0.52) | IGF1RTNK2NEK2FGFR1KDR | |
| SCHEMBL401241 | 0.76 | IGF1R (0.44) | IGF1RTNK2NEK2FGFR1KDR | |
| SCHEMBL4245387 | 0.76 | TNK2 (0.49) | IGF1RTNK2JAK2NEK2ADORA3 | |
| SCHEMBL398892 | 0.76 | IGF1R (0.45) | IGF1RTNK2NEK2ADORA2AFGFR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008076143-A1 | COMBINATION OF IGFR INHIBITOR AND ANTI-CANCER AGENT | OSI PHARMACEUTICALS, INC. (US) | 2008-06-26 | — | — | WO | disclosed |