Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNK2 | Q07912 | 1/20 | 0.42 |
| ▸ | IGF1R | P08069 | 4/20 | 0.40 |
| ▸ | PIP5K1C | O60331 | 6/20 | 0.40 |
| ▸ | PIK3CA | P42336 | 6/20 | 0.40 |
| ▸ | ABL1 | P00519 | 2/20 | 0.39 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.37 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.37 |
| ▸ | JAK2 | O60674 | 1/20 | 0.36 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.36 |
| ▸ | PIP5K1B | O14986 | 1/20 | 0.36 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.36 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.36 |
| ▸ | PI4KA | P42356 | 1/20 | 0.36 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.36 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.36 |
| ▸ | PIP5K1A | Q99755 | 1/20 | 0.36 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.36 |
| ▸ | ACVRL1 | P37023 | 1/20 | 0.36 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.35 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5080636 | 0.91 | IGF1R (0.48) | TNK2IGF1RPIP5K1CPIK3CAABL1 | |
| SCHEMBL5086076 | 0.86 | IGF1R (0.44) | TNK2IGF1RABL1ADORA2AADORA1 | |
| SCHEMBL5086253 | 0.85 | TNK2 (0.50) | TNK2IGF1RABL1 | |
| SCHEMBL5080364 | 0.84 | IGF1R (0.36) | TNK2IGF1RADORA2AADORA1 | |
| SCHEMBL5082567 | 0.83 | IGF1R (0.44) | TNK2IGF1RADORA2AADORA1JAK2 | |
| SCHEMBL5083298 | 0.82 | IGF1R (0.40) | TNK2IGF1RADORA2AADORA1 | |
| SCHEMBL4073244 | 0.79 | IGF1R (0.51) | TNK2IGF1R | |
| SCHEMBL5087010 | 0.79 | IGF1R (0.39) | TNK2IGF1RABL1PIK3CDPIK3CG | |
| SCHEMBL400509 | 0.79 | TNK2 (0.67) | TNK2IGF1R | |
| SCHEMBL5084882 | 0.76 | IGF1R (0.48) | TNK2IGF1RSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008076143-A1 | COMBINATION OF IGFR INHIBITOR AND ANTI-CANCER AGENT | OSI PHARMACEUTICALS, INC. (US) | 2008-06-26 | — | — | WO | disclosed |